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EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis

Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth factor receptor (EGFR) signaling and type XVII collagen (COL17A1) proteolysis on age-associated alteration of keratinocyte stem cell dynamic...

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Detalles Bibliográficos
Autores principales:	Nanba, Daisuke, Toki, Fujio, Asakawa, Kyosuke, Matsumura, Hiroyuki, Shiraishi, Ken, Sayama, Koji, Matsuzaki, Kyoichi, Toki, Hiroshi, Nishimura, Emi K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563287/ https://www.ncbi.nlm.nih.gov/pubmed/34550317 http://dx.doi.org/10.1083/jcb.202012073

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