Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity

A polarized collecting duct (CD), formed from the branching ureteric bud (UB), is a prerequisite for an intact kidney. The small Rho GTPase Rac1 is critical for actin cytoskeletal regulation. We investigated the role of Rac1 in the kidney collecting system by selectively deleting it in mice at the i...

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Detalles Bibliográficos
Autores principales: Bock, Fabian, Elias, Bertha C., Dong, Xinyu, Parekh, Diptiben V., Mernaugh, Glenda, Viquez, Olga M., Hassan, Anjana, Amara, Venkateswara Rao, Liu, Jiageng, Brown, Kyle L., Terker, Andrew S., Chiusa, Manuel, Gewin, Leslie S., Fogo, Agnes B., Brakebusch, Cord H., Pozzi, Ambra, Zent, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563289/
https://www.ncbi.nlm.nih.gov/pubmed/34647970
http://dx.doi.org/10.1083/jcb.202103080

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