Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies

The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply timely and important health information. Most of t...

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Autores principales: Patel, Rashmi, Khare, Siddharth, Mahajan, Vinay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563348/
https://www.ncbi.nlm.nih.gov/pubmed/35153048
http://dx.doi.org/10.1016/j.cll.2021.10.007
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author Patel, Rashmi
Khare, Siddharth
Mahajan, Vinay S.
author_facet Patel, Rashmi
Khare, Siddharth
Mahajan, Vinay S.
author_sort Patel, Rashmi
collection PubMed
description The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply timely and important health information. Most of these serologic assays were based on a conventional enzyme-linked immunosorbent assay or the lateral flow assay format. The immunoassays that were developed were based on alternative technologies and are highlighted in this article with a brief discussion of the assay principle and the pros and cons for each assay. Measurement of neutralizing antibodies is also discussed.
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spelling pubmed-85633482021-11-03 Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies Patel, Rashmi Khare, Siddharth Mahajan, Vinay S. Clin Lab Med Article The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply timely and important health information. Most of these serologic assays were based on a conventional enzyme-linked immunosorbent assay or the lateral flow assay format. The immunoassays that were developed were based on alternative technologies and are highlighted in this article with a brief discussion of the assay principle and the pros and cons for each assay. Measurement of neutralizing antibodies is also discussed. Elsevier Inc. 2022-03 2021-11-03 /pmc/articles/PMC8563348/ /pubmed/35153048 http://dx.doi.org/10.1016/j.cll.2021.10.007 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Patel, Rashmi
Khare, Siddharth
Mahajan, Vinay S.
Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title_full Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title_fullStr Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title_full_unstemmed Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title_short Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
title_sort alternative methods to detect severe acute respiratory syndrome coronavirus 2 antibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563348/
https://www.ncbi.nlm.nih.gov/pubmed/35153048
http://dx.doi.org/10.1016/j.cll.2021.10.007
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