Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses

Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and th...

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Autores principales: Ogata, Alana F., Lazarovits, Roey, Uwamanzu-Nna, Augusta, Gilboa, Tal, Cheng, Chi-An, Walt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563368/
https://www.ncbi.nlm.nih.gov/pubmed/35153051
http://dx.doi.org/10.1016/j.cll.2021.10.002
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author Ogata, Alana F.
Lazarovits, Roey
Uwamanzu-Nna, Augusta
Gilboa, Tal
Cheng, Chi-An
Walt, David R.
author_facet Ogata, Alana F.
Lazarovits, Roey
Uwamanzu-Nna, Augusta
Gilboa, Tal
Cheng, Chi-An
Walt, David R.
author_sort Ogata, Alana F.
collection PubMed
description Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection.
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spelling pubmed-85633682021-11-03 Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses Ogata, Alana F. Lazarovits, Roey Uwamanzu-Nna, Augusta Gilboa, Tal Cheng, Chi-An Walt, David R. Clin Lab Med Article Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection. Elsevier Inc. 2022-03 2021-11-03 /pmc/articles/PMC8563368/ /pubmed/35153051 http://dx.doi.org/10.1016/j.cll.2021.10.002 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ogata, Alana F.
Lazarovits, Roey
Uwamanzu-Nna, Augusta
Gilboa, Tal
Cheng, Chi-An
Walt, David R.
Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title_full Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title_fullStr Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title_full_unstemmed Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title_short Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
title_sort severe acute respiratory syndrome coronavirus 2 antigens as targets of antibody responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563368/
https://www.ncbi.nlm.nih.gov/pubmed/35153051
http://dx.doi.org/10.1016/j.cll.2021.10.002
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