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CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

In chronic infections and in cancer, persistent antigen stimulation under suboptimal conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are characterized by an increased expression of inhibitory markers and a progressive and hierarchical loss of function. Although cancer-in...

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Detalles Bibliográficos
Autores principales:	Miggelbrink, Alexandra M., Jackson, Joshua D., Lorrey, Selena J., Srinivasan, Ethan S., Waibl-Polania, Jessica, Wilkinson, Daniel S., Fecci, Peter E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563372/ https://www.ncbi.nlm.nih.gov/pubmed/34127507 http://dx.doi.org/10.1158/1078-0432.CCR-21-0206

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