Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma

Cancer cells must overcome anoikis (detachment-induced death) to successfully metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 receptor accessory protein (IL1RAP) to suppress anoikis. IL1RAP is directly induced by oncogenic fusions of Ewing sarcoma, a highly m...

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Detalles Bibliográficos
Autores principales: Zhang, Hai-Feng, Hughes, Christopher S., Li, Wei, He, Jian-Zhong, Surdez, Didier, El-Naggar, Amal M., Cheng, Hongwei, Prudova, Anna, Delaidelli, Alberto, Negri, Gian Luca, Li, Xiaojun, Ørum-Madsen, Maj Sofie, Lizardo, Michael M., Oo, Htoo Zarni, Colborne, Shane, Shyp, Taras, Scopim-Ribeiro, Renata, Hammond, Colin A., Dhez, Anne-Chloe, Langman, Sofya, Lim, Jonathan K.M., Kung, Sonia H.Y., Li, Amy, Steino, Anne, Daugaard, Mads, Parker, Seth J., Geltink, Ramon I. Klein, Orentas, Rimas J., Xu, Li-Yan, Morin, Gregg B., Delattre, Olivier, Dimitrov, Dimiter S., Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563374/
https://www.ncbi.nlm.nih.gov/pubmed/34021002
http://dx.doi.org/10.1158/2159-8290.CD-20-1690

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