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FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1

Aneuploid mucinous colorectal adenocarcinoma (MAC) is an aggressive subtype of colorectal cancer with poor prognosis. The tumorigenic mechanisms in aneuploid MAC are currently unknown. Here we show that downregulation of Filamin A–interacting protein 1-like (FILIP1L) is a driver of MAC. Loss of FILI...

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Detalles Bibliográficos
Autores principales:	Kwon, Mijung, Rubio, Genesaret, Nolan, Nicholas, Auteri, Peter, Volmar, Jean Arly, Adem, Asha, Javidian, Parisa, Zhou, Zhongren, Verzi, Michael P., Pine, Sharon R., Libutti, Steven K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Tumor Biology and Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563430/ https://www.ncbi.nlm.nih.gov/pubmed/34417201 http://dx.doi.org/10.1158/0008-5472.CAN-21-0897

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