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Application of machine learning classifiers for microcomputed tomography data assessment of mouse bone microarchitecture
The current standard approach for analyzing cortical bone structure and trabecular bone microarchitecture from micro-computed tomography (microCT) is through classic parametric (e.g., ANOVA, Student's T-test) and nonparametric (e.g., Mann-Whitney U test) statistical tests and the reporting of p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563473/ https://www.ncbi.nlm.nih.gov/pubmed/34754768 http://dx.doi.org/10.1016/j.mex.2021.101497 |
Sumario: | The current standard approach for analyzing cortical bone structure and trabecular bone microarchitecture from micro-computed tomography (microCT) is through classic parametric (e.g., ANOVA, Student's T-test) and nonparametric (e.g., Mann-Whitney U test) statistical tests and the reporting of p-values to indicate significance. However, on their own, these univariate assessments of significance fall prey to a number of weaknesses, including an increased chance of Type 1 error from multiple comparisons. Machine learning classification methods (e.g., unsupervised, k-means cluster analysis and supervised Support Vector Machine classification, SVM) simultaneously utilize an entire dataset comprised of many cortical structure or trabecular microarchitecture measures, thus minimizing bias and Type 1 error that are generated through multiple testing. Through simultaneous evaluation of an entire dataset, k-means and SVM thus provide a complementary approach to classic statistical analysis and enable a more robust assessment of microCT measures. |
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