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Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases
Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563578/ https://www.ncbi.nlm.nih.gov/pubmed/34744700 http://dx.doi.org/10.3389/fnagi.2021.765395 |
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author | Li, Tianbai Tan, Xiang Li, Song Al-Nusaif, Murad Le, Weidong |
author_facet | Li, Tianbai Tan, Xiang Li, Song Al-Nusaif, Murad Le, Weidong |
author_sort | Li, Tianbai |
collection | PubMed |
description | Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND. |
format | Online Article Text |
id | pubmed-8563578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85635782021-11-04 Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases Li, Tianbai Tan, Xiang Li, Song Al-Nusaif, Murad Le, Weidong Front Aging Neurosci Neuroscience Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8563578/ /pubmed/34744700 http://dx.doi.org/10.3389/fnagi.2021.765395 Text en Copyright © 2021 Li, Tan, Li, Al-Nusaif and Le. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Li, Tianbai Tan, Xiang Li, Song Al-Nusaif, Murad Le, Weidong Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title | Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title_full | Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title_fullStr | Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title_full_unstemmed | Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title_short | Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases |
title_sort | role of glia-derived extracellular vesicles in neurodegenerative diseases |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563578/ https://www.ncbi.nlm.nih.gov/pubmed/34744700 http://dx.doi.org/10.3389/fnagi.2021.765395 |
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