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Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy structures of MC4R–Gs-protein complexes with two...

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Detalles Bibliográficos
Autores principales:	Heyder, Nicolas A., Kleinau, Gunnar, Speck, David, Schmidt, Andrea, Paisdzior, Sarah, Szczepek, Michal, Bauer, Brian, Koch, Anja, Gallandi, Monique, Kwiatkowski, Dennis, Bürger, Jörg, Mielke, Thorsten, Beck-Sickinger, Annette G., Hildebrand, Peter W., Spahn, Christian M. T., Hilger, Daniel, Schacherl, Magdalena, Biebermann, Heike, Hilal, Tarek, Kühnen, Peter, Kobilka, Brian K., Scheerer, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563958/ https://www.ncbi.nlm.nih.gov/pubmed/34561620 http://dx.doi.org/10.1038/s41422-021-00569-8

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