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Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making

Intracranial atherosclerotic disease (ICAD) is a dynamic process that leads to ischemic stroke. Symptomatic ICAD patients still suffer a high recurrent rate even under standard treatment. In this case report, to better understand the response of intracranial atherosclerotic plaques to medication, se...

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Autores principales: Xiao, Jiayu, Padrick, Matthew M., Song, Shlee S., Fan, Zhaoyang, Schlick, Konrad H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564011/
https://www.ncbi.nlm.nih.gov/pubmed/34744611
http://dx.doi.org/10.3389/fnins.2021.739178
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author Xiao, Jiayu
Padrick, Matthew M.
Song, Shlee S.
Fan, Zhaoyang
Schlick, Konrad H.
author_facet Xiao, Jiayu
Padrick, Matthew M.
Song, Shlee S.
Fan, Zhaoyang
Schlick, Konrad H.
author_sort Xiao, Jiayu
collection PubMed
description Intracranial atherosclerotic disease (ICAD) is a dynamic process that leads to ischemic stroke. Symptomatic ICAD patients still suffer a high recurrent rate even under standard treatment. In this case report, to better understand the response of intracranial atherosclerotic plaques to medication, serial MR imaging was added to standard clinical workup in a 47-year-old male patient with acute occipital lobe infarction at baseline, 3-month, 6-month, and 12-month post index stroke to directly visualize the morphology and signal change of plaques. We noticed that one of the plaques showed dramatic worsening at 3-month imaging follow-up despite a decrease in low-density lipoprotein level. Early identification of patients who do not respond well to medication is critical to prevent the recurrence of cardiovascular events in ICAD patients.
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spelling pubmed-85640112021-11-04 Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making Xiao, Jiayu Padrick, Matthew M. Song, Shlee S. Fan, Zhaoyang Schlick, Konrad H. Front Neurosci Neuroscience Intracranial atherosclerotic disease (ICAD) is a dynamic process that leads to ischemic stroke. Symptomatic ICAD patients still suffer a high recurrent rate even under standard treatment. In this case report, to better understand the response of intracranial atherosclerotic plaques to medication, serial MR imaging was added to standard clinical workup in a 47-year-old male patient with acute occipital lobe infarction at baseline, 3-month, 6-month, and 12-month post index stroke to directly visualize the morphology and signal change of plaques. We noticed that one of the plaques showed dramatic worsening at 3-month imaging follow-up despite a decrease in low-density lipoprotein level. Early identification of patients who do not respond well to medication is critical to prevent the recurrence of cardiovascular events in ICAD patients. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8564011/ /pubmed/34744611 http://dx.doi.org/10.3389/fnins.2021.739178 Text en Copyright © 2021 Xiao, Padrick, Song, Fan and Schlick. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xiao, Jiayu
Padrick, Matthew M.
Song, Shlee S.
Fan, Zhaoyang
Schlick, Konrad H.
Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title_full Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title_fullStr Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title_full_unstemmed Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title_short Case Report: Serial MR Vessel Wall Imaging Visualizes the Response of Intracranial Plaques and Assists in Decision-Making
title_sort case report: serial mr vessel wall imaging visualizes the response of intracranial plaques and assists in decision-making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564011/
https://www.ncbi.nlm.nih.gov/pubmed/34744611
http://dx.doi.org/10.3389/fnins.2021.739178
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