Design of a randomised, double-blind, crossover, placebo-controlled trial of effects of sildenafil on cerebrovascular function in small vessel disease: Oxford haemodynamic adaptation to reduce pulsatility trial (OxHARP)

BACKGROUND: Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsatility, endothelial dysfunction, and impaired vascular reactivity. Vasodilating phosphodiesterase inhibitors may improve cardiovascular pulsatility and reactivity, and potentially reduce progression of...

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Detalles Bibliográficos
Autores principales: Webb, Alastair, Werring, David, Dawson, Jesse, Rothman, Alex, Lawson, Amy, Wartolowska, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564163/
https://www.ncbi.nlm.nih.gov/pubmed/34746425
http://dx.doi.org/10.1177/23969873211026698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564163/
https://www.ncbi.nlm.nih.gov/pubmed/34746425
http://dx.doi.org/10.1177/23969873211026698

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