Automated Diagnosis and Localization of Melanoma from Skin Histopathology Slides Using Deep Learning: A Multicenter Study

In traditional hospital systems, diagnosis and localization of melanoma are the critical challenges for pathological analysis, treatment instructions, and prognosis evaluation particularly in skin diseases. In literature, various studies have been reported to address these issues; however, a prominent smart diagnosis system is needed to be developed for the smart healthcare system. In this study, a deep learning-enabled diagnostic system is proposed and implemented that it has the capacity to automatically detect malignant melanoma in whole slide images (WSIs). In this system, the convolutional neural network (CNN), sophisticated statistical method, and image processing algorithms were integrated and implemented to locate benign and malignant lesions which are extremely useful in the diagnoses process of melanoma disease. To verify the exceptional performance of the proposed scheme, it is implemented in a multicenter database, which has 701 WSIs (641 WSIs from Central South University Xiangya Hospital (CSUXH) and 60 WSIs from the Cancer Genome Atlas (TCGA)). Experimental results have verified that the proposed system has achieved an area under the receiver operating characteristic curve (AUROC) of 0.971. Furthermore, the lesion area on the WSIs is represented by its degree of malignancy. These results show that the proposed system has the capacity to fully automate the diagnosis and localization problem of the melanoma in the smart healthcare systems.