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Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we exam...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564339/ https://www.ncbi.nlm.nih.gov/pubmed/34551213 http://dx.doi.org/10.1002/2211-5463.13303 |
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author | Ali, Amjad Shafarin, Jasmin Abu Jabal, Rola Aljabi, Nour Hamad, Mohamad Sualeh Muhammad, Jibran Unnikannan, Hema Hamad, Mawieh |
author_facet | Ali, Amjad Shafarin, Jasmin Abu Jabal, Rola Aljabi, Nour Hamad, Mohamad Sualeh Muhammad, Jibran Unnikannan, Hema Hamad, Mawieh |
author_sort | Ali, Amjad |
collection | PubMed |
description | Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC. |
format | Online Article Text |
id | pubmed-8564339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85643392021-11-09 Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC Ali, Amjad Shafarin, Jasmin Abu Jabal, Rola Aljabi, Nour Hamad, Mohamad Sualeh Muhammad, Jibran Unnikannan, Hema Hamad, Mawieh FEBS Open Bio Research Articles Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC. John Wiley and Sons Inc. 2021-10-06 /pmc/articles/PMC8564339/ /pubmed/34551213 http://dx.doi.org/10.1002/2211-5463.13303 Text en © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Ali, Amjad Shafarin, Jasmin Abu Jabal, Rola Aljabi, Nour Hamad, Mohamad Sualeh Muhammad, Jibran Unnikannan, Hema Hamad, Mawieh Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title | Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title_full | Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title_fullStr | Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title_full_unstemmed | Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title_short | Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC |
title_sort | ferritin heavy chain (fth1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐myc |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564339/ https://www.ncbi.nlm.nih.gov/pubmed/34551213 http://dx.doi.org/10.1002/2211-5463.13303 |
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