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Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC

Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we exam...

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Autores principales: Ali, Amjad, Shafarin, Jasmin, Abu Jabal, Rola, Aljabi, Nour, Hamad, Mohamad, Sualeh Muhammad, Jibran, Unnikannan, Hema, Hamad, Mawieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564339/
https://www.ncbi.nlm.nih.gov/pubmed/34551213
http://dx.doi.org/10.1002/2211-5463.13303
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author Ali, Amjad
Shafarin, Jasmin
Abu Jabal, Rola
Aljabi, Nour
Hamad, Mohamad
Sualeh Muhammad, Jibran
Unnikannan, Hema
Hamad, Mawieh
author_facet Ali, Amjad
Shafarin, Jasmin
Abu Jabal, Rola
Aljabi, Nour
Hamad, Mohamad
Sualeh Muhammad, Jibran
Unnikannan, Hema
Hamad, Mawieh
author_sort Ali, Amjad
collection PubMed
description Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC.
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spelling pubmed-85643392021-11-09 Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC Ali, Amjad Shafarin, Jasmin Abu Jabal, Rola Aljabi, Nour Hamad, Mohamad Sualeh Muhammad, Jibran Unnikannan, Hema Hamad, Mawieh FEBS Open Bio Research Articles Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC. John Wiley and Sons Inc. 2021-10-06 /pmc/articles/PMC8564339/ /pubmed/34551213 http://dx.doi.org/10.1002/2211-5463.13303 Text en © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ali, Amjad
Shafarin, Jasmin
Abu Jabal, Rola
Aljabi, Nour
Hamad, Mohamad
Sualeh Muhammad, Jibran
Unnikannan, Hema
Hamad, Mawieh
Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title_full Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title_fullStr Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title_full_unstemmed Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title_short Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
title_sort ferritin heavy chain (fth1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐myc
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564339/
https://www.ncbi.nlm.nih.gov/pubmed/34551213
http://dx.doi.org/10.1002/2211-5463.13303
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