The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea

Sleep apnea is a highly prevalent disorder with increasing impact on healthcare systems worldwide. Previous studies have been conducted primarily with male subjects, and prevalence and severity of sleep apnea in women are underestimated. Recent clinical and basic science evidence increasingly points...

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Autores principales: Hegner, Philipp, Lebek, Simon, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564381/
https://www.ncbi.nlm.nih.gov/pubmed/34744785
http://dx.doi.org/10.3389/fphys.2021.741896
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author Hegner, Philipp
Lebek, Simon
Maier, Lars Siegfried
Arzt, Michael
Wagner, Stefan
author_facet Hegner, Philipp
Lebek, Simon
Maier, Lars Siegfried
Arzt, Michael
Wagner, Stefan
author_sort Hegner, Philipp
collection PubMed
description Sleep apnea is a highly prevalent disorder with increasing impact on healthcare systems worldwide. Previous studies have been conducted primarily with male subjects, and prevalence and severity of sleep apnea in women are underestimated. Recent clinical and basic science evidence increasingly points to different mechanisms in men and women with sleep-disordered breathing (SDB). SDB is associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes, and atrial fibrillation. In this review, we discuss sex-dependent mechanisms of SDB in select associated conditions to sharpen our clinical understanding of these sex-dependent inherent differences.
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spelling pubmed-85643812021-11-04 The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea Hegner, Philipp Lebek, Simon Maier, Lars Siegfried Arzt, Michael Wagner, Stefan Front Physiol Physiology Sleep apnea is a highly prevalent disorder with increasing impact on healthcare systems worldwide. Previous studies have been conducted primarily with male subjects, and prevalence and severity of sleep apnea in women are underestimated. Recent clinical and basic science evidence increasingly points to different mechanisms in men and women with sleep-disordered breathing (SDB). SDB is associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes, and atrial fibrillation. In this review, we discuss sex-dependent mechanisms of SDB in select associated conditions to sharpen our clinical understanding of these sex-dependent inherent differences. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8564381/ /pubmed/34744785 http://dx.doi.org/10.3389/fphys.2021.741896 Text en Copyright © 2021 Hegner, Lebek, Maier, Arzt and Wagner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Hegner, Philipp
Lebek, Simon
Maier, Lars Siegfried
Arzt, Michael
Wagner, Stefan
The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title_full The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title_fullStr The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title_full_unstemmed The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title_short The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea
title_sort effect of gender and sex hormones on cardiovascular disease, heart failure, diabetes, and atrial fibrillation in sleep apnea
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564381/
https://www.ncbi.nlm.nih.gov/pubmed/34744785
http://dx.doi.org/10.3389/fphys.2021.741896
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