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Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner

Voltage-gated Ca(2+) (Cav) channels consist of a pore-forming Cavα1 subunit and auxiliary Cavα2-δ and Cavβ subunits. In fibroblasts, Cavβ3, independent of its role as a Cav subunit, reduces the sensitivity to low concentrations of inositol-1,4,5-trisphosphate (IP(3)). Similarly, Cavβ3 could affect c...

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Detalles Bibliográficos
Autores principales:	Becker, Alexander, Wardas, Barbara, Salah, Houssein, Amini, Maryam, Fecher-Trost, Claudia, Sen, Qiao, Martus, Damian, Beck, Andreas, Philipp, Stephan E., Flockerzi, Veit, Belkacemi, Anouar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564405/ https://www.ncbi.nlm.nih.gov/pubmed/34426509 http://dx.doi.org/10.2337/db21-0078

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