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Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

Throughout evolution, proinsulin has exhibited significant sequence variation in both C-peptide and insulin moieties. As the proinsulin coding sequence evolves, the gene product continues to be under selection pressure both for ultimate insulin bioactivity and for the ability of proinsulin to be fol...

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Detalles Bibliográficos
Autores principales:	Alam, Maroof, Arunagiri, Anoop, Haataja, Leena, Torres, Mauricio, Larkin, Dennis, Kappler, John, Jin, Niyun, Arvan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564407/ https://www.ncbi.nlm.nih.gov/pubmed/34462258 http://dx.doi.org/10.2337/db21-0422

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