β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut-specific SENP1 knockout (pSENP1-KO) mice on a high-fat diet...

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Detalles Bibliográficos
Autores principales: Lin, Haopeng, Smith, Nancy, Spigelman, Aliya F., Suzuki, Kunimasa, Ferdaoussi, Mourad, Alghamdi, Tamadher A., Lewandowski, Sophie L., Jin, Yaxing, Bautista, Austin, Wang, Ying Wayne, Manning Fox, Jocelyn E., Merrins, Matthew J., Buteau, Jean, MacDonald, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564408/
https://www.ncbi.nlm.nih.gov/pubmed/34462260
http://dx.doi.org/10.2337/db20-1235

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