Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumor formation. In an attempt to answer this question, a mouse m...

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Detalles Bibliográficos
Autores principales: Lei, Josh Haipeng, Lee, Mi‐Hye, Miao, Kai, Huang, Zebin, Yao, Zhicheng, Zhang, Aiping, Xu, Jun, Zhao, Ming, Huang, Zenan, Zhang, Xin, Chen, Si, Jiaying, NG, Feng, Yuzhao, Xing, Fuqiang, Chen, Ping, Sun, Heng, Chen, Qiang, Xiang, Tingxiu, Chen, Lin, Xu, Xiaoling, Deng, Chu‐Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564435/
https://www.ncbi.nlm.nih.gov/pubmed/34514747
http://dx.doi.org/10.1002/advs.202100974

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