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Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder
Alcohol use disorder (AUD) has been related to aberrant functional connectivity (FC) in the salience network (SN), executive control network (ECN), and default mode network (DMN). However, there is a lack of comprehensive and simultaneous examination of these networks in patients with AUD and of the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564495/ https://www.ncbi.nlm.nih.gov/pubmed/34744834 http://dx.doi.org/10.3389/fpsyt.2021.742228 |
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author | Suk, Ji-Woo Hwang, Soonjo Cheong, Chaejoon |
author_facet | Suk, Ji-Woo Hwang, Soonjo Cheong, Chaejoon |
author_sort | Suk, Ji-Woo |
collection | PubMed |
description | Alcohol use disorder (AUD) has been related to aberrant functional connectivity (FC) in the salience network (SN), executive control network (ECN), and default mode network (DMN). However, there is a lack of comprehensive and simultaneous examination of these networks in patients with AUD and of their relation to potential anatomical changes. We aimed to comprehensively examine the alteration in FC in the three networks in AUD patients, and the correlation of the alteration with anatomical/structural changes (volume) in the neural areas implicated in these networks, by applying voxel-based morphometry (VBM) and region of interest-to-region of interest connectivity analysis simultaneously. In all, 22 patients with AUD and 22 healthy adults participated in the study and underwent T1 magnetic resonance imaging. Patients with AUD showed increased FCs within the DMN and SN networks, especially in terms of connectivity of the frontal areas and bilateral hippocampi. They also showed decreased FCs in the ECN. In addition, there was significant volume reduction in these areas (frontal areas and hippocampus). The increased FCs within the frontal areas or bilateral hippocampi showed a negative correlation with gray matter volume of these areas in AUD patients. Our findings add to the empirical evidence that the frontal lobe and hippocampi are critical areas that are vulnerable to functional and structural changes due to AUD. |
format | Online Article Text |
id | pubmed-8564495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85644952021-11-04 Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder Suk, Ji-Woo Hwang, Soonjo Cheong, Chaejoon Front Psychiatry Psychiatry Alcohol use disorder (AUD) has been related to aberrant functional connectivity (FC) in the salience network (SN), executive control network (ECN), and default mode network (DMN). However, there is a lack of comprehensive and simultaneous examination of these networks in patients with AUD and of their relation to potential anatomical changes. We aimed to comprehensively examine the alteration in FC in the three networks in AUD patients, and the correlation of the alteration with anatomical/structural changes (volume) in the neural areas implicated in these networks, by applying voxel-based morphometry (VBM) and region of interest-to-region of interest connectivity analysis simultaneously. In all, 22 patients with AUD and 22 healthy adults participated in the study and underwent T1 magnetic resonance imaging. Patients with AUD showed increased FCs within the DMN and SN networks, especially in terms of connectivity of the frontal areas and bilateral hippocampi. They also showed decreased FCs in the ECN. In addition, there was significant volume reduction in these areas (frontal areas and hippocampus). The increased FCs within the frontal areas or bilateral hippocampi showed a negative correlation with gray matter volume of these areas in AUD patients. Our findings add to the empirical evidence that the frontal lobe and hippocampi are critical areas that are vulnerable to functional and structural changes due to AUD. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8564495/ /pubmed/34744834 http://dx.doi.org/10.3389/fpsyt.2021.742228 Text en Copyright © 2021 Suk, Hwang and Cheong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Suk, Ji-Woo Hwang, Soonjo Cheong, Chaejoon Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title | Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title_full | Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title_fullStr | Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title_full_unstemmed | Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title_short | Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder |
title_sort | functional and structural alteration of default mode, executive control, and salience networks in alcohol use disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564495/ https://www.ncbi.nlm.nih.gov/pubmed/34744834 http://dx.doi.org/10.3389/fpsyt.2021.742228 |
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