Cargando…

Decreased mortality and increased side effects in COVID-19 patients treated with IL-6 receptor antagonists: systematic review and meta-analysis

There is controversy whether IL-6 (receptor) antagonists are beneficial in treating COVID-19 patients. We therefore update our systematic review to answer the following research questions: (1) Do patients hospitalized for COVID-19 treated with IL-6 (receptor) antagonists have lower mortality compare...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malgie, Jishnu, Schoones, Jan W., Zeegers, Maurice P., Pijls, Bart G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564515/ https://www.ncbi.nlm.nih.gov/pubmed/34728658 http://dx.doi.org/10.1038/s41598-021-00726-4

Ejemplares similares

Decreased mortality in COVID-19 patients treated with Tocilizumab: a rapid systematic review and meta-analysis of observational studies
por: Malgie, Jishnu, et al.
Publicado: (2020)

Custom triflange acetabular components for large acetabular defect reconstruction in revision total hip arthroplasty: a systematic review and meta-analysis on 1218 patients
por: Broekhuis, Demien, et al.
Publicado: (2023)

Haemodynamic monitoring as an opportunity for tailoring diuretics and guideline‐directed medical therapy in heart failure
por: Malgie, Jishnu, et al.
Publicado: (2023)

RSA prediction of high failure rate for the uncoated Interax TKA confirmed by meta-analysis
por: Pijls, Bart G, et al.
Publicado: (2012)

Modular component exchange and outcome of DAIR for hip and knee periprosthetic joint infection: a systematic review and meta-regression analysis
por: Gerritsen, Maxime, et al.
Publicado: (2021)

Increased Mortality in Metal-on-Metal versus Non-Metal-on-Metal Primary Total Hip Arthroplasty at 10 Years and Longer Follow-Up: A Systematic Review and Meta-Analysis
por: Pijls, B. G., et al.
Publicado: (2016)

Ethnic minority status as social determinant for COVID-19 infection, hospitalisation, severity, ICU admission and deaths in the early phase of the pandemic: a meta-analysis
por: Agyemang, Charles, et al.
Publicado: (2021)

Guideline-directed medical therapy for HFrEF: sequencing strategies and barriers for life-saving drug therapy
por: Malgie, Jishnu, et al.
Publicado: (2023)

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies
por: Blanchetot, Christophe, et al.
Publicado: (2016)

Interleukin-6 (IL-6) Receptor Antagonist Protects Against Rheumatoid Arthritis
por: Li, Songsong, et al.
Publicado: (2016)

Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model
por: Kovacs, Eva
Publicado: (2006)

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells
Publicado: (1994)

ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro
por: Yu, Dandan, et al.
Publicado: (2015)

Recurrent poliserositis succesfully treated with IL-1 receptor antagonist Anakinra
por: Lovillo, MS Camacho, et al.
Publicado: (2011)

Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
por: Purohit, A, et al.
Publicado: (2003)

Antimicrobial activity of ion-substituted calcium phosphates: A systematic review
por: Kamphof, Robert, et al.
Publicado: (2023)

Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies
por: Pijls, Bart G, et al.
Publicado: (2021)

Temporal trends of sex differences for COVID-19 infection, hospitalisation, severe disease, intensive care unit (ICU) admission and death: a meta-analysis of 229 studies covering over 10M patients
por: Pijls, Bart G., et al.
Publicado: (2022)

IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection
por: Tissi, Luciana, et al.
Publicado: (2009)

Increased Serum IL 6 Associated With Mortality and Cognitive Impairment in Elderly Brazilians
por: Caldeira, Marcelo, et al.
Publicado: (2020)

Severe South American Ocular Toxoplasmosis Is Associated with Decreased Ifn-γ/Il-17a and Increased Il-6/Il-13 Intraocular Levels
por: de-la-Torre, Alejandra, et al.
Publicado: (2013)

Older age, female sex, and increased IL-6 decrease the organ yield from cadaveric donors
por: Raghavan, M, et al.
Publicado: (2006)

A New Approach to the Management of COVID-19. Antagonists of IL-6: Siltuximab
por: Villaescusa, Lucinda, et al.
Publicado: (2022)

Outcomes and biomarker analyses among patients with COVID-19 treated with interleukin 6 (IL-6) receptor antagonist sarilumab at a single institution in Italy
por: Montesarchio, Vincenzo, et al.
Publicado: (2020)

Inhaled Corticosteroids, Vitamin K Antagonists and Amlodipine Were Associated with an Increased Risk of Acute Periprosthetic Joint Infection in Patients with Total Hip Arthroplasty: A Retrospective Case–Cohort Study
por: Bruin, Maarten M., et al.
Publicado: (2022)

Severe sepsis caused by serious gastrointestinal infection in sJIA patients treated with IL-6 receptor antagonist: a case report
por: Xu, Meng, et al.
Publicado: (2020)

Correction: Outcomes and biomarker analyses among patients with COVID-19 treated with interleukin 6 (IL-6) receptor antagonist sarilumab at a single institution in Italy
Publicado: (2020)

Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD
por: Jiang, Shenghua, et al.
Publicado: (2018)

Side effects of the leukotriene receptor antagonists in asthmatic children
por: Can, Demet, et al.
Publicado: (2015)

Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children
por: Erdem, Semiha Bahceci, et al.
Publicado: (2015)

The IL-6 antagonist tocilizumab is associated with worse depression and related symptoms in the medically ill
por: Knight, Jennifer M., et al.
Publicado: (2021)

A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6
por: Liao, Liping, et al.
Publicado: (2022)

Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6
por: REIS, CÁTIA, et al.
Publicado: (2014)

Reflections on the RSA guidelines
por: Pijls, Bart G
Publicado: (2020)

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation
por: Amini, Zhaleh N., et al.
Publicado: (2015)

Antidepressants of the Serotonin-Antagonist Type Increase Body Fat and Decrease Lifespan of Adult Caenorhabditis elegans
por: Zarse, Kim, et al.
Publicado: (2008)

IL-1 receptor antagonist restores IL-18 NK cell axis in systemic JIA
por: Vastert, Sebastiaan J, et al.
Publicado: (2012)

HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β
por: Tawara, Ken, et al.
Publicado: (2019)

Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells
por: Müller, Hanna, et al.
Publicado: (2015)

Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis
por: Askari, Alireza, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_que9j7m0ohnfv6g6khhkm00qmc