The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer

The tumor suppressor PTEN is disrupted in a large proportion of cancers, including in HER2-positive breast cancer, where its loss is associated with resistance to therapy. Upon genotoxic stress, ataxia telangiectasia mutated (ATM) is activated and phosphorylates PTEN on residue 398. To elucidate the...

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Detalles Bibliográficos
Autores principales: Bassi, Christian, Fortin, Jerome, Snow, Bryan E., Wakeham, Andrew, Ho, Jason, Haight, Jillian, You-Ten, Annick, Cianci, Emily, Buckler, Luke, Gorrini, Chiara, Stambolic, Vuk, Mak, Tak W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564521/
https://www.ncbi.nlm.nih.gov/pubmed/34059798
http://dx.doi.org/10.1038/s41418-021-00799-8

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