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Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

SHP2 mediates the activities of multiple receptor tyrosine kinase signaling and its function in endothelial processes has been explored extensively. However, genetic studies on the role of SHP2 in tumor angiogenesis have not been conducted. Here, we show that SHP2 is activated in tumor endothelia. S...

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Detalles Bibliográficos
Autores principales:	Xu, Zhiyong, Guo, Chunyi, Ye, Qiaoli, Shi, Yueli, Sun, Yihui, Zhang, Jie, Huang, Jiaqi, Huang, Yizhou, Zeng, Chunlai, Zhang, Xue, Ke, Yuehai, Cheng, Hongqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564544/ https://www.ncbi.nlm.nih.gov/pubmed/34728626 http://dx.doi.org/10.1038/s41467-021-26697-8

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