FANCD2 limits acetaldehyde‐induced genomic instability during DNA replication in esophageal keratinocytes

Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young‐onset head and neck squamous cell carcinomas (SCCs) and esophageal SCC. The FA DNA repair pathway is activated upon DNA damage induced by acetaldehyde, a chief alcohol metabolite and on...

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Detalles Bibliográficos
Autores principales: Peake, Jasmine D., Noguchi, Chiaki, Lin, Baicheng, Theriault, Amber, O'Connor, Margaret, Sheth, Shivani, Tanaka, Koji, Nakagawa, Hiroshi, Noguchi, Eishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564632/
https://www.ncbi.nlm.nih.gov/pubmed/34328261
http://dx.doi.org/10.1002/1878-0261.13072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564632/
https://www.ncbi.nlm.nih.gov/pubmed/34328261
http://dx.doi.org/10.1002/1878-0261.13072

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