Cargando…

LAMC1 upregulation via TGFβ induces inflammatory cancer‐associated fibroblasts in esophageal squamous cell carcinoma via NF‐κB–CXCL1–STAT3

Cancer‐associated fibroblasts (CAF) are a heterogeneous cell population within the tumor microenvironment,and play an important role in tumor development. By regulating the heterogeneity of CAF, transforming growth factor β (TGFβ) influences tumor development. Here, we explored oncogenes regulated b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Lingling, Che, Yun, Zhang, Chaoqi, Huang, Jianbing, Lei, Yuanyuan, Lu, Zhiliang, Sun, Nan, He, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564640/ https://www.ncbi.nlm.nih.gov/pubmed/34218518 http://dx.doi.org/10.1002/1878-0261.13053

Ejemplares similares

PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway
por: Fang, Lingling, et al.
Publicado: (2021)

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta
por: O’Connor, Richard A., et al.
Publicado: (2023)

High LAMC1 expression in glioma is associated with poor prognosis
por: Liu, Jian, et al.
Publicado: (2019)

EBV-Induced CXCL8 Upregulation Promotes Vasculogenic Mimicry in Gastric Carcinoma via NF-κB Signaling
por: Zhang, Jing-yue, et al.
Publicado: (2022)

Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway
por: Shaw, Abhirup, et al.
Publicado: (2021)

TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling
por: Lu, Zhiliang, et al.
Publicado: (2018)

LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein
por: Liang, Yan, et al.
Publicado: (2018)

Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients
por: Qiao, Min, et al.
Publicado: (2022)

CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways
por: Chen, Xiaona, et al.
Publicado: (2021)

Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L
por: Saidi, Ahlame, et al.
Publicado: (2019)

HSP90/IKK‐rich small extracellular vesicles activate pro‐angiogenic melanoma‐associated fibroblasts via the NF‐κB/CXCL1 axis
por: Tang, Hokeung, et al.
Publicado: (2022)

Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance
por: Che, Yun, et al.
Publicado: (2018)

Calcium-sensing receptor promotes high glucose-induced myocardial fibrosis via upregulation of the TGF-β(1)/Smads pathway in cardiac fibroblasts
por: Yuan, Hui, et al.
Publicado: (2019)

The TGFβ-Induced Long Non-coding RNA TBULC Promotes the Invasion and Migration of Non-small Cell Lung Cancer Cells and Indicates Poor Prognosis
por: Zheng, Sufei, et al.
Publicado: (2019)

Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway
por: Lu, Zhiliang, et al.
Publicado: (2017)

CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma
por: Kim, Eun Kyoung, et al.
Publicado: (2018)

Variants in LAMC3 Causes Occipital Cortical Malformation
por: Qian, Xiaohang, et al.
Publicado: (2021)

LAMC2 is a potential prognostic biomarker for cholangiocarcinoma
por: Ong, Khaa Hoo, et al.
Publicado: (2023)

Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway
por: Liu, Jiafei, et al.
Publicado: (2019)

Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1
por: Lee, Wonhwa, et al.
Publicado: (2020)

Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population
por: Chen, Juan, et al.
Publicado: (2020)

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer
por: Kunitomi, Haruko, et al.
Publicado: (2019)

Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation
por: He, Qin, et al.
Publicado: (2021)

Blocking the CXCL1-CXCR2 axis enhances the effects of doxorubicin in HCC by remodelling the tumour microenvironment via the NF-κB/IL-1β/CXCL1 signalling pathway
por: Zhao, Huiyong, et al.
Publicado: (2023)

Cx43 upregulation in HUVECs under stretch via TGF-β1 and cytoskeletal network
por: Shi, Yumeng, et al.
Publicado: (2022)

Upregulation of Atypical Cadherin FAT1 Promotes an Immunosuppressive Tumor Microenvironment via TGF-β
por: Irshad, Khushboo, et al.
Publicado: (2022)

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1
por: Yang, Zike, et al.
Publicado: (2018)

Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5
por: Li, Ziqian, et al.
Publicado: (2019)

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1
por: BUJOR, ANDREEA M., et al.
Publicado: (2012)

RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF-β1/Smad pathway
por: Guo, Yu, et al.
Publicado: (2021)

LAMC1 is a Novel Prognostic Factor and a Potential Therapeutic Target in Gastric Cancer
por: Xi, Dayong, et al.
Publicado: (2022)

Herbal Medication, Macmoondong Decoction, Attenuates LPS-Induced COPD in Small Airways via TGF-β, CCL-2, and CXCL1
por: Lee, Soon-Young, et al.
Publicado: (2020)

Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro
por: Wang, Shiwei, et al.
Publicado: (2023)

GDNF triggers proliferation of rat C6 glioma cells via the NF-κB/CXCL1 signaling pathway
por: Wang, Yue, et al.
Publicado: (2023)

FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway
por: Yang, Yonghong, et al.
Publicado: (2014)

Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis
por: Yang, Jia-Lian, et al.
Publicado: (2020)

Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling
por: Liu, Shasha, et al.
Publicado: (2021)

LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression
por: Yu, Zhi, et al.
Publicado: (2022)

TGF-β1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts
por: Ahn, Keun Jae, et al.
Publicado: (2022)

Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma
por: Ahn, Hak Jun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9e1o2tg989r22jh2u2smdv6s4n