SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis

Hot spot gene mutations in splicing factor 3b subunit 1 (SF3B1) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis. Here, we identified that the SF3B1 K700E (SF3B1(K700E)) mutation is strongly associated with tumor growth...

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Detalles Bibliográficos
Autores principales: Yang, Jian‐Yu, Huo, Yan‐Miao, Yang, Min‐Wei, Shen, Yang, Liu, De‐Jun, Fu, Xue‐Liang, Tao, Ling‐Ye, He, Rui‐Zhe, Zhang, Jun‐Feng, Hua, Rong, Jiang, Shu‐Heng, Sun, Yong‐Wei, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564647/
https://www.ncbi.nlm.nih.gov/pubmed/33932092
http://dx.doi.org/10.1002/1878-0261.12970

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