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Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities

Unique among metazoan repressive histone methyltransferases, G9a and GLP, which chiefly target histone 3 lysine 9 (H3K9), require dimerization for productive H3K9 mono (me1)- and dimethylation (me2) in vivo. Intriguingly, even though each enzyme can independently methylate H3K9, the predominant acti...

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Detalles Bibliográficos
Autores principales:	Sanchez, Nicholas A., Kallweit, Lena M., Trnka, Michael J., Clemmer, Charles L., Al-Sady, Bassem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Accelerated Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564726/ https://www.ncbi.nlm.nih.gov/pubmed/34619147 http://dx.doi.org/10.1016/j.jbc.2021.101276

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