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SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT

Spontaneous resolution of nonfunctioning pituitary adenoma after hemorrhagic apoplexy is a rare clinical entity of unknown etiology and is defined as disappearance of a tumor without any specific treatment. Here we present a 54-year-old male patient who presented with acute onset of severe headache,...

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Autores principales: Komić, Luka, Kruljac, Ivan, Mirošević, Gorana, Gaćina, Petar, Pećina, Hrvoje Ivan, Čerina, Vatroslav, Gajski, Domagoj, Blaslov, Kristina, Rotim, Krešimir, Vrkljan, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564843/
https://www.ncbi.nlm.nih.gov/pubmed/34744285
http://dx.doi.org/10.20471/acc.2021.60.02.21
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author Komić, Luka
Kruljac, Ivan
Mirošević, Gorana
Gaćina, Petar
Pećina, Hrvoje Ivan
Čerina, Vatroslav
Gajski, Domagoj
Blaslov, Kristina
Rotim, Krešimir
Vrkljan, Milan
author_facet Komić, Luka
Kruljac, Ivan
Mirošević, Gorana
Gaćina, Petar
Pećina, Hrvoje Ivan
Čerina, Vatroslav
Gajski, Domagoj
Blaslov, Kristina
Rotim, Krešimir
Vrkljan, Milan
author_sort Komić, Luka
collection PubMed
description Spontaneous resolution of nonfunctioning pituitary adenoma after hemorrhagic apoplexy is a rare clinical entity of unknown etiology and is defined as disappearance of a tumor without any specific treatment. Here we present a 54-year-old male patient who presented with acute onset of severe headache, vomiting, photophobia, and sonophobia. He was referred to brain computed tomography, which showed a 16x12x16 mm tumor mass located in the sellar region with signs of hemorrhage. Endocrinologic evaluation was consistent with under-function of pituitary gonadotropic cells. Magnetic resonance imaging (MRI) performed ten days later was consistent with hemorrhagic apoplexy of the pituitary adenoma. The patient’s symptoms resolved after conservative treatment with dexamethasone, but he was scheduled for elective pituitary surgery. Preoperative MRI was performed one month after the first one and disclosed normal pituitary gland without any signs of adenoma. Our case is remarkable due to the fact that spontaneous remission of pituitary adenoma occurred within the first month, which is the shortest interval reported to date. Our case highlights the importance of conservative therapy as the first-line treatment for pituitary apoplexy in the absence of neurological impairment, since spontaneous remission may occur in a short time interval.
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spelling pubmed-85648432021-11-04 SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT Komić, Luka Kruljac, Ivan Mirošević, Gorana Gaćina, Petar Pećina, Hrvoje Ivan Čerina, Vatroslav Gajski, Domagoj Blaslov, Kristina Rotim, Krešimir Vrkljan, Milan Acta Clin Croat Case Reports Spontaneous resolution of nonfunctioning pituitary adenoma after hemorrhagic apoplexy is a rare clinical entity of unknown etiology and is defined as disappearance of a tumor without any specific treatment. Here we present a 54-year-old male patient who presented with acute onset of severe headache, vomiting, photophobia, and sonophobia. He was referred to brain computed tomography, which showed a 16x12x16 mm tumor mass located in the sellar region with signs of hemorrhage. Endocrinologic evaluation was consistent with under-function of pituitary gonadotropic cells. Magnetic resonance imaging (MRI) performed ten days later was consistent with hemorrhagic apoplexy of the pituitary adenoma. The patient’s symptoms resolved after conservative treatment with dexamethasone, but he was scheduled for elective pituitary surgery. Preoperative MRI was performed one month after the first one and disclosed normal pituitary gland without any signs of adenoma. Our case is remarkable due to the fact that spontaneous remission of pituitary adenoma occurred within the first month, which is the shortest interval reported to date. Our case highlights the importance of conservative therapy as the first-line treatment for pituitary apoplexy in the absence of neurological impairment, since spontaneous remission may occur in a short time interval. Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2021-06 /pmc/articles/PMC8564843/ /pubmed/34744285 http://dx.doi.org/10.20471/acc.2021.60.02.21 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Case Reports
Komić, Luka
Kruljac, Ivan
Mirošević, Gorana
Gaćina, Petar
Pećina, Hrvoje Ivan
Čerina, Vatroslav
Gajski, Domagoj
Blaslov, Kristina
Rotim, Krešimir
Vrkljan, Milan
SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title_full SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title_fullStr SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title_full_unstemmed SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title_short SPONTANEOUS RESOLUTION OF A NONFUNCTIONING PITUITARY ADENOMA OVER ONE-MONTH PERIOD: A CASE REPORT
title_sort spontaneous resolution of a nonfunctioning pituitary adenoma over one-month period: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564843/
https://www.ncbi.nlm.nih.gov/pubmed/34744285
http://dx.doi.org/10.20471/acc.2021.60.02.21
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