Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Endothelial dysfunction accompanies the microvascular thrombosis commonly observed in severe COVID-19. Constitutively, the endothelial surface is anticoagulant, a property maintained at least in part via signaling through the Tie2 receptor. During inflammation, the Tie2 antagonist angiopoietin-2 (An...

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Detalles Bibliográficos
Autores principales: Schmaier, Alec A., Pajares Hurtado, Gabriel M., Manickas-Hill, Zachary J., Sack, Kelsey D., Chen, Siyu M., Bhambhani, Victoria, Quadir, Juweria, Nath, Anjali K., Collier, Ai-ris Y., Ngo, Debby, Barouch, Dan H., Shapiro, Nathan I., Gerszten, Robert E., Yu, Xu G., Peters, Kevin G., Flaumenhaft, Robert, Parikh, Samir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564889/
https://www.ncbi.nlm.nih.gov/pubmed/34506304
http://dx.doi.org/10.1172/jci.insight.151527

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