Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer

BACKGROUND: Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromatase substrate androstenedione. We hypothesized that...

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Detalles Bibliográficos
Autores principales: Kruse, Megan L., Patel, Mona, McManus, Jeffrey, Chung, Yoon-Mi, Li, Xiuxiu, Wei, Wei, Bazeley, Peter S., Nakamura, Fumihiko, Hardaway, Aimalie, Downs, Erinn, Chandarlapaty, Sarat, Thomas, Mathew, Moore, Halle C.F., Budd, George T., Tang, W.H. Wilson, Hazen, Stanley L., Bernstein, Aaron, Nik-Zainal, Serena, Abraham, Jame, Sharifi, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564898/
https://www.ncbi.nlm.nih.gov/pubmed/34520399
http://dx.doi.org/10.1172/jci.insight.150403

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