Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

BACKGROUND: Observational studies suggest interconnections between thyroid status, metabolism, and risk of coronary artery disease (CAD), but causality remains to be proven. The present study aimed to investigate the potential causal relationship between thyroid status and cardiovascular disease and...

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Detalles Bibliográficos
Autores principales: van Vliet, Nicolien A., Bos, Maxime M., Thesing, Carisha S., Chaker, Layal, Pietzner, Maik, Houtman, Evelyn, Neville, Matt J., Li-Gao, Ruifang, Trompet, Stella, Mustafa, Rima, Ahmadizar, Fariba, Beekman, Marian, Bot, Mariska, Budde, Kathrin, Christodoulides, Constantinos, Dehghan, Abbas, Delles, Christian, Elliott, Paul, Evangelou, Marina, Gao, He, Ghanbari, Mohsen, van Herwaarden, Antonius E., Ikram, M. Arfan, Jaeger, Martin, Jukema, J. Wouter, Karaman, Ibrahim, Karpe, Fredrik, Kloppenburg, Margreet, Meessen, Jennifer M. T. A., Meulenbelt, Ingrid, Milaneschi, Yuri, Mooijaart, Simon P., Mook-Kanamori, Dennis O., Netea, Mihai G., Netea-Maier, Romana T., Peeters, Robin P., Penninx, Brenda W. J. H., Sattar, Naveed, Slagboom, P. Eline, Suchiman, H. Eka D., Völzke, Henry, Willems van Dijk, Ko, Noordam, Raymond, van Heemst, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565073/
https://www.ncbi.nlm.nih.gov/pubmed/34727949
http://dx.doi.org/10.1186/s12916-021-02130-1

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