Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate

ABSTRACT: Kinetics of Permanganate (MnO(4)(−)) oxidation of antiviral drug, valacyclovir hydrochloride (VCH) has been studied spectrophotometrically at a constant ionic strength of 0.1 mol dm(−3). The reaction exhibiting a 2:1 stoichiometry (MnO(4)(−):VCH) has been studied over a wide range of exper...

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Detalles Bibliográficos
Autores principales: Tuwar, Suresh M, Hanabaratti, Rohini M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565177/
https://www.ncbi.nlm.nih.gov/pubmed/34751205
http://dx.doi.org/10.1007/s12039-021-01969-4
Descripción
Sumario:ABSTRACT: Kinetics of Permanganate (MnO(4)(−)) oxidation of antiviral drug, valacyclovir hydrochloride (VCH) has been studied spectrophotometrically at a constant ionic strength of 0.1 mol dm(−3). The reaction exhibiting a 2:1 stoichiometry (MnO(4)(−):VCH) has been studied over a wide range of experimental conditions. It was found that the rate enhancement was associated with an increase in concentrations of alkali, reductant and temperature. A plausible mechanism involving an intermediate Mn(VII)-VCH complex (C) was expected and rate law is derived accordingly. Calculated activation parameters also supported the anticipated mechanism. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12039-021-01969-4.

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