Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-mediated end-joining (MMEJ). Here, we investigate Polθ repair o...

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Detalles Bibliográficos
Autores principales: Chandramouly, Gurushankar, Liao, Shuren, Rusanov, Timur, Borisonnik, Nikita, Calbert, Marissa L., Kent, Tatiana, Sullivan-Reed, Katherine, Vekariya, Umeshkumar, Kashkina, Ekaterina, Skorski, Tomasz, Yan, Hong, Pomerantz, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565190/
https://www.ncbi.nlm.nih.gov/pubmed/33691100
http://dx.doi.org/10.1016/j.celrep.2021.108820

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