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Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties

The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca(2+) ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7, and 8...

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Autores principales: Salarbashi, Davoud, Tafaghodi, Mohsen, Fathi, Morteza, aboutorabzade, Seyyed Mohammad, Sabbagh, Farzaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565235/
https://www.ncbi.nlm.nih.gov/pubmed/34760242
http://dx.doi.org/10.1002/fsn3.2562
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author Salarbashi, Davoud
Tafaghodi, Mohsen
Fathi, Morteza
aboutorabzade, Seyyed Mohammad
Sabbagh, Farzaneh
author_facet Salarbashi, Davoud
Tafaghodi, Mohsen
Fathi, Morteza
aboutorabzade, Seyyed Mohammad
Sabbagh, Farzaneh
author_sort Salarbashi, Davoud
collection PubMed
description The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca(2+) ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7, and 8) and ion concentrations (1, 3, and 5) on the particle diameter and surface charge of the samples were examined. The encapsulation efficiency in the PAGE‐based nanoparticles was realized to be 86.1%, indicating the encapsulation technique applied in this study was effective to entrap most of the curcumin within the PAGE matrix. The nanoparticles showed a smooth surface with spherical shape. Fourier transform infrared spectroscopy (FT‐IR) and X‐ray diffraction (X‐ray) studies confirmed the formation of polyelectrolyte complexation. The cumulative release of curcumin in simulated gastrointestinal tract was less than 75%, revealing a gradual release trend. Both pure curcumin and curcumin‐loaded nanoparticles were toxic to the cancer cell lines.
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spelling pubmed-85652352021-11-09 Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties Salarbashi, Davoud Tafaghodi, Mohsen Fathi, Morteza aboutorabzade, Seyyed Mohammad Sabbagh, Farzaneh Food Sci Nutr Original Research The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca(2+) ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7, and 8) and ion concentrations (1, 3, and 5) on the particle diameter and surface charge of the samples were examined. The encapsulation efficiency in the PAGE‐based nanoparticles was realized to be 86.1%, indicating the encapsulation technique applied in this study was effective to entrap most of the curcumin within the PAGE matrix. The nanoparticles showed a smooth surface with spherical shape. Fourier transform infrared spectroscopy (FT‐IR) and X‐ray diffraction (X‐ray) studies confirmed the formation of polyelectrolyte complexation. The cumulative release of curcumin in simulated gastrointestinal tract was less than 75%, revealing a gradual release trend. Both pure curcumin and curcumin‐loaded nanoparticles were toxic to the cancer cell lines. John Wiley and Sons Inc. 2021-09-08 /pmc/articles/PMC8565235/ /pubmed/34760242 http://dx.doi.org/10.1002/fsn3.2562 Text en © 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Salarbashi, Davoud
Tafaghodi, Mohsen
Fathi, Morteza
aboutorabzade, Seyyed Mohammad
Sabbagh, Farzaneh
Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_full Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_fullStr Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_full_unstemmed Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_short Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_sort development of curcumin‐loaded prunus armeniaca gum nanoparticles: synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565235/
https://www.ncbi.nlm.nih.gov/pubmed/34760242
http://dx.doi.org/10.1002/fsn3.2562
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