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A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA

Mutations in mitochondrial DNA (mtDNA) cause maternally inherited diseases, while somatic mutations are linked to common diseases of aging. Although mtDNA mutations impact health, the processes that give rise to them are under considerable debate. To investigate the mechanism by which de novo mutati...

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Detalles Bibliográficos
Autores principales:	Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Kohrn, Brendan F, Tsantilas, Kristine A, Hipp, Michael J, Schmidt, Elizabeth K, Fredrickson, Jeanne, Whitson, Jeremy A, Campbell, Matthew D, Rabinovitch, Peter S, Marcinek, David J, Kennedy, Scott R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565317/ https://www.ncbi.nlm.nih.gov/pubmed/34614167 http://dx.doi.org/10.1093/nar/gkab901

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