USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM

The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism, and genetic stability. Loss of function mutations in BLM cause the genetic instability/cancer predisposition syndrome Bloom syndrome. However, the molecular mechanism underlying the regulation of BLM in cancers remai...

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Detalles Bibliográficos
Autores principales: Wu, Chenming, Chang, Yiming, Chen, Junliang, Su, Yang, Li, Lei, Chen, Yuping, Li, Yunhui, Wu, Jinhuan, Huang, Jinzhou, Zhao, Fei, Wang, Wenrui, Yin, Hui, Wang, Shunli, Jin, Mingpeng, Lou, Zhenkun, Zhu, Wei-Guo, Luo, Kuntian, Zhang, Jie, Yuan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565321/
https://www.ncbi.nlm.nih.gov/pubmed/34606619
http://dx.doi.org/10.1093/nar/gkab842

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