Uniform affinity-tuning of N-methyl-aminoacyl-tRNAs to EF-Tu enhances their multiple incorporation

In ribosomal translation, the accommodation of aminoacyl-tRNAs into the ribosome is mediated by elongation factor thermo unstable (EF-Tu). The structures of proteinogenic aminoacyl-tRNAs (pAA-tRNAs) are fine-tuned to have uniform binding affinities to EF-Tu in order that all proteinogenic amino acid...

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Detalles Bibliográficos
Autores principales: Iwane, Yoshihiko, Kimura, Hiroyuki, Katoh, Takayuki, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565323/
https://www.ncbi.nlm.nih.gov/pubmed/33997906
http://dx.doi.org/10.1093/nar/gkab288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565323/
https://www.ncbi.nlm.nih.gov/pubmed/33997906
http://dx.doi.org/10.1093/nar/gkab288

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