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Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of multiple cancers, including colorectal cancer, but the underlying precise molecular mechanisms remain elusive. Herein we model the radiosensitivity of isogenic HCT116 and SW48 colorectal cancer cell lines bear...

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Detalles Bibliográficos
Autores principales:	Yang, Linlin, Shen, Changxian, Estrada-Bernal, Adriana, Robb, Ryan, Chatterjee, Moumita, Sebastian, Nikhil, Webb, Amy, Mo, Xiaokui, Chen, Wei, Krishnan, Sunil, Williams, Terence M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565339/ https://www.ncbi.nlm.nih.gov/pubmed/34606602 http://dx.doi.org/10.1093/nar/gkab871

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