STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells

Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, we analyze the genomic distribution of STAG1 and STAG2 and perform STAG2 los...

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Detalles Bibliográficos
Autores principales: Richart, Laia, Lapi, Eleonora, Pancaldi, Vera, Cuenca-Ardura, Mirabai, Pau, Enrique Carrillo-de-Santa, Madrid-Mencía, Miguel, Neyret-Kahn, Hélène, Radvanyi, François, Rodríguez, Juan Antonio, Cuartero, Yasmina, Serra, François, Le Dily, François, Valencia, Alfonso, Marti-Renom, Marc A, Real, Francisco X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565347/
https://www.ncbi.nlm.nih.gov/pubmed/34648034
http://dx.doi.org/10.1093/nar/gkab864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565347/
https://www.ncbi.nlm.nih.gov/pubmed/34648034
http://dx.doi.org/10.1093/nar/gkab864

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