Cargando…

STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells

Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, we analyze the genomic distribution of STAG1 and STAG2 and perform STAG2 los...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richart, Laia, Lapi, Eleonora, Pancaldi, Vera, Cuenca-Ardura, Mirabai, Pau, Enrique Carrillo-de-Santa, Madrid-Mencía, Miguel, Neyret-Kahn, Hélène, Radvanyi, François, Rodríguez, Juan Antonio, Cuartero, Yasmina, Serra, François, Le Dily, François, Valencia, Alfonso, Marti-Renom, Marc A, Real, Francisco X
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565347/ https://www.ncbi.nlm.nih.gov/pubmed/34648034 http://dx.doi.org/10.1093/nar/gkab864

Ejemplares similares

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion
por: Serna-Pujol, Núria, et al.
Publicado: (2022)

PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
por: Mayayo-Peralta, Isabel, et al.
Publicado: (2023)

A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
por: Zaurin, Roser, et al.
Publicado: (2021)

Parallel sequencing lives, or what makes large sequencing projects successful
por: Quilez, Javier, et al.
Publicado: (2017)

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy
por: Balbás-Martínez, Cristina, et al.
Publicado: (2013)

BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells
por: Chiang, Huai-Chin, et al.
Publicado: (2019)

OneD: increasing reproducibility of Hi-C samples with abnormal karyotypes
por: Vidal, Enrique, et al.
Publicado: (2018)

The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression
por: Larochelle, Marc, et al.
Publicado: (2012)

Characterization of new regulatory elements within the Drosophila bithorax complex
por: Pérez-Lluch, Sílvia, et al.
Publicado: (2008)

Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast
por: Yague-Sanz, Carlo, et al.
Publicado: (2021)

Global inhibition of transcription causes an increase in histone H2A.Z incorporation within gene bodies
por: Lashgari, Anahita, et al.
Publicado: (2017)

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus
por: Junier, Ivan, et al.
Publicado: (2012)

Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1
por: Bentrari, Fatima, et al.
Publicado: (2015)

Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes
por: Uwimana, Nicole, et al.
Publicado: (2017)

The histone demethylase Kdm3a is essential to progression through differentiation
por: Herzog, Marielle, et al.
Publicado: (2012)

Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing
por: Lai, Xuelei, et al.
Publicado: (2020)

DNA of a circular minichromosome linearized by restriction enzymes or other reagents is resistant to further cleavage: an influence of chromatin topology on the accessibility of DNA
por: Kumala, Sławomir, et al.
Publicado: (2012)

Regulation of alginate catabolism involves a GntR family repressor in the marine flavobacterium Zobellia galactanivorans Dsij(T)
por: Dudek, Magda, et al.
Publicado: (2020)

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation
por: Deplus, Rachel, et al.
Publicado: (2014)

Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control
por: Gimenez, Juliette, et al.
Publicado: (2010)

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation
por: Dubois-Chevalier, Julie, et al.
Publicado: (2014)

Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context
por: Le Noir, Sandrine, et al.
Publicado: (2017)

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements(†)
por: Millau, Jean-François, et al.
Publicado: (2011)

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages
por: Daniel, Bence, et al.
Publicado: (2018)

Tetramerization of MADS family transcription factors SEPALLATA3 and AGAMOUS is required for floral meristem determinacy in Arabidopsis
por: Hugouvieux, Véronique, et al.
Publicado: (2018)

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
por: Stadhouders, Ralph, et al.
Publicado: (2018)

The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides
por: Yan, Yifei, et al.
Publicado: (2018)

Species-specific regulation of XIST by the JPX/FTX orthologs
por: Rosspopoff, Olga, et al.
Publicado: (2023)

Molecular basis for the methylation specificity of ATXR5 for histone H3
por: Bergamin, Elisa, et al.
Publicado: (2017)

Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock
por: Amat, Ramon, et al.
Publicado: (2019)

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
por: van der Lelij, Petra, et al.
Publicado: (2017)

Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia
por: Ridinger-Saison, Maya, et al.
Publicado: (2012)

Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners
por: Marcelot, Agathe, et al.
Publicado: (2021)

Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo
por: Derakhshan, Maria, et al.
Publicado: (2022)

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
por: Pascual-Reguant, Laura, et al.
Publicado: (2018)

The Epstein–Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
por: Coppotelli, Giuseppe, et al.
Publicado: (2013)

A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells
por: Eymery, Angéline, et al.
Publicado: (2009)

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity
por: McCann, Alex J, et al.
Publicado: (2021)

A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA
por: García-Oliver, Encar, et al.
Publicado: (2013)

Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation
por: Fujii, Satoshi, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_c9ij2hc146rb216iriu58kvi3i