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Learning the structure–activity relationship (SAR) of the Wittig reaction from genetically-encoded substrates

The Wittig reaction can be used for late stage functionalization of proteins and peptides to ligate glycans, pharmacophores, and many other functionalities. In this manuscript, we modified 160 000 N-terminal glyoxaldehyde peptides displayed on phage with the Wittig reaction by using a biotin labeled...

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Detalles Bibliográficos
Autores principales:	Yan, Kejia, Triana, Vivian, Kalmady, Sunil Vasu, Aku-Dominguez, Kwami, Memon, Sharyar, Brown, Alex, Greiner, Russell, Derda, Ratmir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565473/ https://www.ncbi.nlm.nih.gov/pubmed/34760216 http://dx.doi.org/10.1039/d1sc04146k

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