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Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit

OBJECTIVE: This research aimed to evaluate whether the neutrophil to lymphocyte and platelet (N/LP) ratio may be used to predict the risk of admission to the intensive care unit (ICU), the need for mechanical ventilation and in-hospital mortality in Coronavirus disease 2019 (COVID-19) cases. METHODS...

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Autores principales: Cakir Guney, Basak, Hayiroglu, Mert, Senocak, Didar, Cİcek, Vedat, Cinar, Tufan, Kaplan, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Istanbul Medeniyet University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565580/
https://www.ncbi.nlm.nih.gov/pubmed/34915683
http://dx.doi.org/10.5222/MMJ.2021.95676
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author Cakir Guney, Basak
Hayiroglu, Mert
Senocak, Didar
Cİcek, Vedat
Cinar, Tufan
Kaplan, Mustafa
author_facet Cakir Guney, Basak
Hayiroglu, Mert
Senocak, Didar
Cİcek, Vedat
Cinar, Tufan
Kaplan, Mustafa
author_sort Cakir Guney, Basak
collection PubMed
description OBJECTIVE: This research aimed to evaluate whether the neutrophil to lymphocyte and platelet (N/LP) ratio may be used to predict the risk of admission to the intensive care unit (ICU), the need for mechanical ventilation and in-hospital mortality in Coronavirus disease 2019 (COVID-19) cases. METHODS: The study was conducted retrospectively on the data of 134 COVID-19 patients who were admitted to the ICU. The N/LP ratio was calculated as follows: neutrophil count x 100 / (lymphocyte count x platelet count). Each member of the research cohort was categorised into 1 of 2 groups based on their survival status (survivor and non-survivor groups). RESULTS: In total, 82 (61%) patients died during the ICU stay. Patients who required mechanical ventilation and died in the ICU stay had significantly higher N/LP ratio than those who did not require it and survived [10 (IQR=4.94-19.38) vs 2.51 (IQR=1.67-5.49), p<0.001] and [11.27 (IQR=4.53-30.02) vs 1.65 (IQR=1-3.24), p<0.001], respectively. The N/LP ratio was linked with the requirement of mechanical ventilation and in-hospital death according to multivariable analysis. In receiver operating characteristic curve analysis, we found that N/LP in predicting admission to the ICU was >4.18 with 61% sensitivity and 62% specificity, it was >5.07 with 74% sensitivity and 73% specificity for the need for mechanical ventilation, and >3.69 with 81% sensitivity and 81% specificity to predict in-hospital death. CONCLUSION: To our knowledge, this is the first study showing that the N/LP ratio, which is a novel and widely applicable inflammatory index, may be used to predict the risk of ICU admission, mechanical ventilation and in-hospital death in patients with COVID-19 disease .
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spelling pubmed-85655802021-11-12 Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit Cakir Guney, Basak Hayiroglu, Mert Senocak, Didar Cİcek, Vedat Cinar, Tufan Kaplan, Mustafa Medeni Med J Original Study OBJECTIVE: This research aimed to evaluate whether the neutrophil to lymphocyte and platelet (N/LP) ratio may be used to predict the risk of admission to the intensive care unit (ICU), the need for mechanical ventilation and in-hospital mortality in Coronavirus disease 2019 (COVID-19) cases. METHODS: The study was conducted retrospectively on the data of 134 COVID-19 patients who were admitted to the ICU. The N/LP ratio was calculated as follows: neutrophil count x 100 / (lymphocyte count x platelet count). Each member of the research cohort was categorised into 1 of 2 groups based on their survival status (survivor and non-survivor groups). RESULTS: In total, 82 (61%) patients died during the ICU stay. Patients who required mechanical ventilation and died in the ICU stay had significantly higher N/LP ratio than those who did not require it and survived [10 (IQR=4.94-19.38) vs 2.51 (IQR=1.67-5.49), p<0.001] and [11.27 (IQR=4.53-30.02) vs 1.65 (IQR=1-3.24), p<0.001], respectively. The N/LP ratio was linked with the requirement of mechanical ventilation and in-hospital death according to multivariable analysis. In receiver operating characteristic curve analysis, we found that N/LP in predicting admission to the ICU was >4.18 with 61% sensitivity and 62% specificity, it was >5.07 with 74% sensitivity and 73% specificity for the need for mechanical ventilation, and >3.69 with 81% sensitivity and 81% specificity to predict in-hospital death. CONCLUSION: To our knowledge, this is the first study showing that the N/LP ratio, which is a novel and widely applicable inflammatory index, may be used to predict the risk of ICU admission, mechanical ventilation and in-hospital death in patients with COVID-19 disease . Istanbul Medeniyet University 2021 2021-09-30 /pmc/articles/PMC8565580/ /pubmed/34915683 http://dx.doi.org/10.5222/MMJ.2021.95676 Text en © Copyright Istanbul Medeniyet University Faculty of Medicine. https://creativecommons.org/licenses/by-nc/4.0/This journal is published by Logos Medical Publishing. Licenced by Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
spellingShingle Original Study
Cakir Guney, Basak
Hayiroglu, Mert
Senocak, Didar
Cİcek, Vedat
Cinar, Tufan
Kaplan, Mustafa
Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title_full Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title_fullStr Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title_full_unstemmed Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title_short Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit
title_sort evaluation of n/lp ratio as a predictor of disease progression and mortality in covid-19 patients admitted to the intensive care unit
topic Original Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565580/
https://www.ncbi.nlm.nih.gov/pubmed/34915683
http://dx.doi.org/10.5222/MMJ.2021.95676
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