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Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes

INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observatio...

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Autores principales: Asare‐Anane, Henry, Ofori, Emmanuel Kwaku, Kwao‐Zigah, Genevieve, Ateko, Richmond O., Annan, Benjamin D. R. T., Adjei, Afua B., Quansah, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565652/
https://www.ncbi.nlm.nih.gov/pubmed/34505408
http://dx.doi.org/10.1002/edm2.70
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author Asare‐Anane, Henry
Ofori, Emmanuel Kwaku
Kwao‐Zigah, Genevieve
Ateko, Richmond O.
Annan, Benjamin D. R. T.
Adjei, Afua B.
Quansah, Michael
author_facet Asare‐Anane, Henry
Ofori, Emmanuel Kwaku
Kwao‐Zigah, Genevieve
Ateko, Richmond O.
Annan, Benjamin D. R. T.
Adjei, Afua B.
Quansah, Michael
author_sort Asare‐Anane, Henry
collection PubMed
description INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observational study. Sixty persons with type 2 diabetes and 60 nondiabetic controls were included in this study. Blood pressure, body mass index (BMI), kisspeptin, luteinizing hormone (LH), follicle‐stimulating hormone (FSH), total testosterone (T), glucose (FBG), glycated haemoglobin (HbA1c) and lipid levels were assessed. RESULTS: Type 2 diabetic men had lower kisspeptin and T concentrations than controls (P = 0.001 for both). Levels of LH and FSH were, respectively, higher in diabetic men compared with their control counterparts (P = 0.003; P = 0.017). There were negative associations within the diabetic group for kisspeptin vs age (r = −0.590, P = 0.0001) and kisspeptin vs BMI (r = −0.389, P = 0.002). Positive associations were also found within the diabetic group for kisspeptin vs T (r = 0.531, P = 0.001), kisspeptin vs LH (r = 0.423, P = 0.001) and kisspeptin vs FSH (r = 0.366, P = 0.004). Lower T (OR = 1.473, P = 0.003) and advancing age (OR = 0.890, P = 0.004) contributed to decreased kisspeptin levels among Ghanaian males with type 2 diabetes. CONCLUSION: Our data demonstrate that circulating kisspeptin and T concentrations are lower among men with type 2 diabetes and highlight the importance of considering kisspeptin concentrations in the management of hypogonadism and type 2 diabetes.
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spelling pubmed-85656522021-11-09 Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes Asare‐Anane, Henry Ofori, Emmanuel Kwaku Kwao‐Zigah, Genevieve Ateko, Richmond O. Annan, Benjamin D. R. T. Adjei, Afua B. Quansah, Michael Endocrinol Diabetes Metab Original Articles INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observational study. Sixty persons with type 2 diabetes and 60 nondiabetic controls were included in this study. Blood pressure, body mass index (BMI), kisspeptin, luteinizing hormone (LH), follicle‐stimulating hormone (FSH), total testosterone (T), glucose (FBG), glycated haemoglobin (HbA1c) and lipid levels were assessed. RESULTS: Type 2 diabetic men had lower kisspeptin and T concentrations than controls (P = 0.001 for both). Levels of LH and FSH were, respectively, higher in diabetic men compared with their control counterparts (P = 0.003; P = 0.017). There were negative associations within the diabetic group for kisspeptin vs age (r = −0.590, P = 0.0001) and kisspeptin vs BMI (r = −0.389, P = 0.002). Positive associations were also found within the diabetic group for kisspeptin vs T (r = 0.531, P = 0.001), kisspeptin vs LH (r = 0.423, P = 0.001) and kisspeptin vs FSH (r = 0.366, P = 0.004). Lower T (OR = 1.473, P = 0.003) and advancing age (OR = 0.890, P = 0.004) contributed to decreased kisspeptin levels among Ghanaian males with type 2 diabetes. CONCLUSION: Our data demonstrate that circulating kisspeptin and T concentrations are lower among men with type 2 diabetes and highlight the importance of considering kisspeptin concentrations in the management of hypogonadism and type 2 diabetes. John Wiley and Sons Inc. 2019-04-21 /pmc/articles/PMC8565652/ /pubmed/34505408 http://dx.doi.org/10.1002/edm2.70 Text en © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Asare‐Anane, Henry
Ofori, Emmanuel Kwaku
Kwao‐Zigah, Genevieve
Ateko, Richmond O.
Annan, Benjamin D. R. T.
Adjei, Afua B.
Quansah, Michael
Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title_full Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title_fullStr Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title_full_unstemmed Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title_short Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
title_sort lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565652/
https://www.ncbi.nlm.nih.gov/pubmed/34505408
http://dx.doi.org/10.1002/edm2.70
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