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Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes
INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565652/ https://www.ncbi.nlm.nih.gov/pubmed/34505408 http://dx.doi.org/10.1002/edm2.70 |
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author | Asare‐Anane, Henry Ofori, Emmanuel Kwaku Kwao‐Zigah, Genevieve Ateko, Richmond O. Annan, Benjamin D. R. T. Adjei, Afua B. Quansah, Michael |
author_facet | Asare‐Anane, Henry Ofori, Emmanuel Kwaku Kwao‐Zigah, Genevieve Ateko, Richmond O. Annan, Benjamin D. R. T. Adjei, Afua B. Quansah, Michael |
author_sort | Asare‐Anane, Henry |
collection | PubMed |
description | INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observational study. Sixty persons with type 2 diabetes and 60 nondiabetic controls were included in this study. Blood pressure, body mass index (BMI), kisspeptin, luteinizing hormone (LH), follicle‐stimulating hormone (FSH), total testosterone (T), glucose (FBG), glycated haemoglobin (HbA1c) and lipid levels were assessed. RESULTS: Type 2 diabetic men had lower kisspeptin and T concentrations than controls (P = 0.001 for both). Levels of LH and FSH were, respectively, higher in diabetic men compared with their control counterparts (P = 0.003; P = 0.017). There were negative associations within the diabetic group for kisspeptin vs age (r = −0.590, P = 0.0001) and kisspeptin vs BMI (r = −0.389, P = 0.002). Positive associations were also found within the diabetic group for kisspeptin vs T (r = 0.531, P = 0.001), kisspeptin vs LH (r = 0.423, P = 0.001) and kisspeptin vs FSH (r = 0.366, P = 0.004). Lower T (OR = 1.473, P = 0.003) and advancing age (OR = 0.890, P = 0.004) contributed to decreased kisspeptin levels among Ghanaian males with type 2 diabetes. CONCLUSION: Our data demonstrate that circulating kisspeptin and T concentrations are lower among men with type 2 diabetes and highlight the importance of considering kisspeptin concentrations in the management of hypogonadism and type 2 diabetes. |
format | Online Article Text |
id | pubmed-8565652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85656522021-11-09 Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes Asare‐Anane, Henry Ofori, Emmanuel Kwaku Kwao‐Zigah, Genevieve Ateko, Richmond O. Annan, Benjamin D. R. T. Adjei, Afua B. Quansah, Michael Endocrinol Diabetes Metab Original Articles INTRODUCTION: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin. METHODS: A cross‐sectional, observational study. Sixty persons with type 2 diabetes and 60 nondiabetic controls were included in this study. Blood pressure, body mass index (BMI), kisspeptin, luteinizing hormone (LH), follicle‐stimulating hormone (FSH), total testosterone (T), glucose (FBG), glycated haemoglobin (HbA1c) and lipid levels were assessed. RESULTS: Type 2 diabetic men had lower kisspeptin and T concentrations than controls (P = 0.001 for both). Levels of LH and FSH were, respectively, higher in diabetic men compared with their control counterparts (P = 0.003; P = 0.017). There were negative associations within the diabetic group for kisspeptin vs age (r = −0.590, P = 0.0001) and kisspeptin vs BMI (r = −0.389, P = 0.002). Positive associations were also found within the diabetic group for kisspeptin vs T (r = 0.531, P = 0.001), kisspeptin vs LH (r = 0.423, P = 0.001) and kisspeptin vs FSH (r = 0.366, P = 0.004). Lower T (OR = 1.473, P = 0.003) and advancing age (OR = 0.890, P = 0.004) contributed to decreased kisspeptin levels among Ghanaian males with type 2 diabetes. CONCLUSION: Our data demonstrate that circulating kisspeptin and T concentrations are lower among men with type 2 diabetes and highlight the importance of considering kisspeptin concentrations in the management of hypogonadism and type 2 diabetes. John Wiley and Sons Inc. 2019-04-21 /pmc/articles/PMC8565652/ /pubmed/34505408 http://dx.doi.org/10.1002/edm2.70 Text en © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Asare‐Anane, Henry Ofori, Emmanuel Kwaku Kwao‐Zigah, Genevieve Ateko, Richmond O. Annan, Benjamin D. R. T. Adjei, Afua B. Quansah, Michael Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title | Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title_full | Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title_fullStr | Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title_full_unstemmed | Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title_short | Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
title_sort | lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565652/ https://www.ncbi.nlm.nih.gov/pubmed/34505408 http://dx.doi.org/10.1002/edm2.70 |
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