Cargando…

The histopathological landscape of the major psoriasiform dermatoses

Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Balan, Raluca, Grigoraş, Adriana, Popovici, Diana, Amălinei, Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: UMF “Gr. T. Popa” Iasi Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565680/
https://www.ncbi.nlm.nih.gov/pubmed/34754910
http://dx.doi.org/10.22551/2019.24.0603.10155
_version_ 1784593860801855488
author Balan, Raluca
Grigoraş, Adriana
Popovici, Diana
Amălinei, Cornelia
author_facet Balan, Raluca
Grigoraş, Adriana
Popovici, Diana
Amălinei, Cornelia
author_sort Balan, Raluca
collection PubMed
description Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. They create a diagnostic challenge, both clinical and histopathological, because of their complexity and frequent overlapping of the microscopical features. The characteristic histopathological features of psoriasiform reaction comprise extensive hyperkeratosis, with horizontally confluent but vertically intermittent parakeratosis, which alternate with orthokeratosis, thin granular layer, with relative frequent mitoses, uniform elongated and fused rete ridges, edematous superficial papillary dermis, with dilated capillaries, perivascular lymphocytic infiltrate, Munro’s microabscesses, and spongiform pustules of Kogoj. Our paper aims to review the histopathology of major form of psoriasiform dermatoses and to emphasize the characteristic microscopical differences between them, for a better approach of the diagnosis as an important key for clinical and therapeutical management. Using the clinicopathological correlations, a thoroughly evaluation of the microscopical features and compartments distribution or special stainings and techniques, the range of differential diagnosis can be decreased and a more accurate diagnostic can be usually achieved. The insights into the pathogenic mechanisms can lead to new therapeutic opportunities targeted to the specific type of inflammatory lesion.
format Online
Article
Text
id pubmed-8565680
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher UMF “Gr. T. Popa” Iasi Publishing House
record_format MEDLINE/PubMed
spelling pubmed-85656802021-11-08 The histopathological landscape of the major psoriasiform dermatoses Balan, Raluca Grigoraş, Adriana Popovici, Diana Amălinei, Cornelia Arch Clin Cases Review Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. They create a diagnostic challenge, both clinical and histopathological, because of their complexity and frequent overlapping of the microscopical features. The characteristic histopathological features of psoriasiform reaction comprise extensive hyperkeratosis, with horizontally confluent but vertically intermittent parakeratosis, which alternate with orthokeratosis, thin granular layer, with relative frequent mitoses, uniform elongated and fused rete ridges, edematous superficial papillary dermis, with dilated capillaries, perivascular lymphocytic infiltrate, Munro’s microabscesses, and spongiform pustules of Kogoj. Our paper aims to review the histopathology of major form of psoriasiform dermatoses and to emphasize the characteristic microscopical differences between them, for a better approach of the diagnosis as an important key for clinical and therapeutical management. Using the clinicopathological correlations, a thoroughly evaluation of the microscopical features and compartments distribution or special stainings and techniques, the range of differential diagnosis can be decreased and a more accurate diagnostic can be usually achieved. The insights into the pathogenic mechanisms can lead to new therapeutic opportunities targeted to the specific type of inflammatory lesion. UMF “Gr. T. Popa” Iasi Publishing House 2021-10-27 /pmc/articles/PMC8565680/ /pubmed/34754910 http://dx.doi.org/10.22551/2019.24.0603.10155 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Balan, Raluca
Grigoraş, Adriana
Popovici, Diana
Amălinei, Cornelia
The histopathological landscape of the major psoriasiform dermatoses
title The histopathological landscape of the major psoriasiform dermatoses
title_full The histopathological landscape of the major psoriasiform dermatoses
title_fullStr The histopathological landscape of the major psoriasiform dermatoses
title_full_unstemmed The histopathological landscape of the major psoriasiform dermatoses
title_short The histopathological landscape of the major psoriasiform dermatoses
title_sort histopathological landscape of the major psoriasiform dermatoses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565680/
https://www.ncbi.nlm.nih.gov/pubmed/34754910
http://dx.doi.org/10.22551/2019.24.0603.10155
work_keys_str_mv AT balanraluca thehistopathologicallandscapeofthemajorpsoriasiformdermatoses
AT grigorasadriana thehistopathologicallandscapeofthemajorpsoriasiformdermatoses
AT popovicidiana thehistopathologicallandscapeofthemajorpsoriasiformdermatoses
AT amalineicornelia thehistopathologicallandscapeofthemajorpsoriasiformdermatoses
AT balanraluca histopathologicallandscapeofthemajorpsoriasiformdermatoses
AT grigorasadriana histopathologicallandscapeofthemajorpsoriasiformdermatoses
AT popovicidiana histopathologicallandscapeofthemajorpsoriasiformdermatoses
AT amalineicornelia histopathologicallandscapeofthemajorpsoriasiformdermatoses