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The histopathological landscape of the major psoriasiform dermatoses
Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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UMF “Gr. T. Popa” Iasi Publishing House
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565680/ https://www.ncbi.nlm.nih.gov/pubmed/34754910 http://dx.doi.org/10.22551/2019.24.0603.10155 |
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author | Balan, Raluca Grigoraş, Adriana Popovici, Diana Amălinei, Cornelia |
author_facet | Balan, Raluca Grigoraş, Adriana Popovici, Diana Amălinei, Cornelia |
author_sort | Balan, Raluca |
collection | PubMed |
description | Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. They create a diagnostic challenge, both clinical and histopathological, because of their complexity and frequent overlapping of the microscopical features. The characteristic histopathological features of psoriasiform reaction comprise extensive hyperkeratosis, with horizontally confluent but vertically intermittent parakeratosis, which alternate with orthokeratosis, thin granular layer, with relative frequent mitoses, uniform elongated and fused rete ridges, edematous superficial papillary dermis, with dilated capillaries, perivascular lymphocytic infiltrate, Munro’s microabscesses, and spongiform pustules of Kogoj. Our paper aims to review the histopathology of major form of psoriasiform dermatoses and to emphasize the characteristic microscopical differences between them, for a better approach of the diagnosis as an important key for clinical and therapeutical management. Using the clinicopathological correlations, a thoroughly evaluation of the microscopical features and compartments distribution or special stainings and techniques, the range of differential diagnosis can be decreased and a more accurate diagnostic can be usually achieved. The insights into the pathogenic mechanisms can lead to new therapeutic opportunities targeted to the specific type of inflammatory lesion. |
format | Online Article Text |
id | pubmed-8565680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | UMF “Gr. T. Popa” Iasi Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-85656802021-11-08 The histopathological landscape of the major psoriasiform dermatoses Balan, Raluca Grigoraş, Adriana Popovici, Diana Amălinei, Cornelia Arch Clin Cases Review Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter’s syndrome, pityriasis rubra pilaris, lichen simplex chronicus and large-plaques parapsoriasis. They create a diagnostic challenge, both clinical and histopathological, because of their complexity and frequent overlapping of the microscopical features. The characteristic histopathological features of psoriasiform reaction comprise extensive hyperkeratosis, with horizontally confluent but vertically intermittent parakeratosis, which alternate with orthokeratosis, thin granular layer, with relative frequent mitoses, uniform elongated and fused rete ridges, edematous superficial papillary dermis, with dilated capillaries, perivascular lymphocytic infiltrate, Munro’s microabscesses, and spongiform pustules of Kogoj. Our paper aims to review the histopathology of major form of psoriasiform dermatoses and to emphasize the characteristic microscopical differences between them, for a better approach of the diagnosis as an important key for clinical and therapeutical management. Using the clinicopathological correlations, a thoroughly evaluation of the microscopical features and compartments distribution or special stainings and techniques, the range of differential diagnosis can be decreased and a more accurate diagnostic can be usually achieved. The insights into the pathogenic mechanisms can lead to new therapeutic opportunities targeted to the specific type of inflammatory lesion. UMF “Gr. T. Popa” Iasi Publishing House 2021-10-27 /pmc/articles/PMC8565680/ /pubmed/34754910 http://dx.doi.org/10.22551/2019.24.0603.10155 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Balan, Raluca Grigoraş, Adriana Popovici, Diana Amălinei, Cornelia The histopathological landscape of the major psoriasiform dermatoses |
title | The histopathological landscape of the major psoriasiform dermatoses |
title_full | The histopathological landscape of the major psoriasiform dermatoses |
title_fullStr | The histopathological landscape of the major psoriasiform dermatoses |
title_full_unstemmed | The histopathological landscape of the major psoriasiform dermatoses |
title_short | The histopathological landscape of the major psoriasiform dermatoses |
title_sort | histopathological landscape of the major psoriasiform dermatoses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565680/ https://www.ncbi.nlm.nih.gov/pubmed/34754910 http://dx.doi.org/10.22551/2019.24.0603.10155 |
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