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Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma
Primary thyroid angiosarcoma is a very rare and extremely aggressive mesenchymal malignant neoplasm showing morphological and immunophenotypic evidence of endothelial cell differentiation. Early diagnosis of this tumor along with radical thyroidectomy followed by postoperative radiotherapy and chemo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
UMF “Gr. T. Popa” Iasi Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565704/ https://www.ncbi.nlm.nih.gov/pubmed/34754933 http://dx.doi.org/10.22551/2021.30.0801.10178 |
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author | Negură, Ion Bădescu, Minerva Codruţa Rezuş, Ciprian Dănilă, Radu Florescu, Alexandru Florin Blaj, Mihaela Moroşan, Eugenia Apostol, Delia Gabriela Ciobanu |
author_facet | Negură, Ion Bădescu, Minerva Codruţa Rezuş, Ciprian Dănilă, Radu Florescu, Alexandru Florin Blaj, Mihaela Moroşan, Eugenia Apostol, Delia Gabriela Ciobanu |
author_sort | Negură, Ion |
collection | PubMed |
description | Primary thyroid angiosarcoma is a very rare and extremely aggressive mesenchymal malignant neoplasm showing morphological and immunophenotypic evidence of endothelial cell differentiation. Early diagnosis of this tumor along with radical thyroidectomy followed by postoperative radiotherapy and chemotherapy are essential for adequate management of the patient. Currently available data on diagnosis and treatment options of this neoplasm are limited because it is a rare disease in endocrine organs. Raising awareness regarding its diagnosis can help to optimize the treatment and to improve the survival of the patient. We present the case of a 72-year-old female patient with multiple comorbidities who addressed to the hospital with obstructive respiratory symptoms: dyspnea, wheezing and hoarseness. The investigations, both clinical and paraclinical, identified a local invasive cervical mass located mainly in the left thyroid lobe, whose immunohistochemical examination confirmed primary thyroid angiosarcoma. Although this type of neoplasm is described mainly in the Alpine regions, it can appear in lower altitude regions and this tumor needs to be differentiated from a high-grade neoplasm (anaplastic thyroid carcinoma). |
format | Online Article Text |
id | pubmed-8565704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | UMF “Gr. T. Popa” Iasi Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-85657042021-11-08 Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma Negură, Ion Bădescu, Minerva Codruţa Rezuş, Ciprian Dănilă, Radu Florescu, Alexandru Florin Blaj, Mihaela Moroşan, Eugenia Apostol, Delia Gabriela Ciobanu Arch Clin Cases Case Report Primary thyroid angiosarcoma is a very rare and extremely aggressive mesenchymal malignant neoplasm showing morphological and immunophenotypic evidence of endothelial cell differentiation. Early diagnosis of this tumor along with radical thyroidectomy followed by postoperative radiotherapy and chemotherapy are essential for adequate management of the patient. Currently available data on diagnosis and treatment options of this neoplasm are limited because it is a rare disease in endocrine organs. Raising awareness regarding its diagnosis can help to optimize the treatment and to improve the survival of the patient. We present the case of a 72-year-old female patient with multiple comorbidities who addressed to the hospital with obstructive respiratory symptoms: dyspnea, wheezing and hoarseness. The investigations, both clinical and paraclinical, identified a local invasive cervical mass located mainly in the left thyroid lobe, whose immunohistochemical examination confirmed primary thyroid angiosarcoma. Although this type of neoplasm is described mainly in the Alpine regions, it can appear in lower altitude regions and this tumor needs to be differentiated from a high-grade neoplasm (anaplastic thyroid carcinoma). UMF “Gr. T. Popa” Iasi Publishing House 2021-10-27 /pmc/articles/PMC8565704/ /pubmed/34754933 http://dx.doi.org/10.22551/2021.30.0801.10178 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Negură, Ion Bădescu, Minerva Codruţa Rezuş, Ciprian Dănilă, Radu Florescu, Alexandru Florin Blaj, Mihaela Moroşan, Eugenia Apostol, Delia Gabriela Ciobanu Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title | Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title_full | Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title_fullStr | Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title_full_unstemmed | Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title_short | Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
title_sort | morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565704/ https://www.ncbi.nlm.nih.gov/pubmed/34754933 http://dx.doi.org/10.22551/2021.30.0801.10178 |
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