Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands...

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Detalles Bibliográficos
Autores principales: Jiang, Lingyan, Yang, Wen, Jiang, Xinlei, Yao, Ting, Wang, Lu, Yang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565820/
https://www.ncbi.nlm.nih.gov/pubmed/34711138
http://dx.doi.org/10.1080/19490976.2021.1992237
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author Jiang, Lingyan
Yang, Wen
Jiang, Xinlei
Yao, Ting
Wang, Lu
Yang, Bin
author_facet Jiang, Lingyan
Yang, Wen
Jiang, Xinlei
Yao, Ting
Wang, Lu
Yang, Bin
author_sort Jiang, Lingyan
collection PubMed
description Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands, compared with the nonpathogenic E. coli K-12 laboratory strain. These O islands contribute largely to the pathogenicity of EHEC O157:H7 by providing numerous virulence factors, effectors, virulence regulatory proteins, and virulence regulatory sRNAs. The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands.
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spelling pubmed-85658202021-11-04 Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7 Jiang, Lingyan Yang, Wen Jiang, Xinlei Yao, Ting Wang, Lu Yang, Bin Gut Microbes Review Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands, compared with the nonpathogenic E. coli K-12 laboratory strain. These O islands contribute largely to the pathogenicity of EHEC O157:H7 by providing numerous virulence factors, effectors, virulence regulatory proteins, and virulence regulatory sRNAs. The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands. Taylor & Francis 2021-10-28 /pmc/articles/PMC8565820/ /pubmed/34711138 http://dx.doi.org/10.1080/19490976.2021.1992237 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Jiang, Lingyan
Yang, Wen
Jiang, Xinlei
Yao, Ting
Wang, Lu
Yang, Bin
Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title_full Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title_fullStr Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title_full_unstemmed Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title_short Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
title_sort virulence-related o islands in enterohemorrhagic escherichia coli o157:h7
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565820/
https://www.ncbi.nlm.nih.gov/pubmed/34711138
http://dx.doi.org/10.1080/19490976.2021.1992237
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