Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer

Multiple mutational signatures have been associated with DNA mismatch repair (MMR)–deficient cancers, but the mechanisms underlying their origin remain unclear. Here, using mutation data from cancer genomes, we identify a previously unknown function of MMR that is able to protect genomes from 5-meth...

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Detalles Bibliográficos
Autores principales: Fang, Hu, Zhu, Xiaoqiang, Yang, Haocheng, Oh, Jieun, Barbour, Jayne A., Wong, Jason W. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565909/
https://www.ncbi.nlm.nih.gov/pubmed/34730999
http://dx.doi.org/10.1126/sciadv.abg4398

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