Targeting Endoglin Expressing Cells in the Tumor Microenvironment Does Not Inhibit Tumor Growth in a Pancreatic Cancer Mouse Model

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer and is known to have low immunogenicity and an immunosuppressive microenvironment. It is also characterized by high accumulation of dense stroma, composed of mostly cancer-associated fibroblasts (CAFs). Mul...

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Detalles Bibliográficos
Autores principales: Schoonderwoerd, Mark J A, Hakuno, Sarah K, Sassen, Martijn, Kuhlemaijer, Eleonore B, Paauwe, Madelon, Slingerland, Marije, Fransen, Marieke F, Hawinkels, Lukas J A C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565992/
https://www.ncbi.nlm.nih.gov/pubmed/34744438
http://dx.doi.org/10.2147/OTT.S322276

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