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Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats
Acupuncture has long been used to relieve some inner ear diseases such as deafness and tinnitus. The present study examined the effect of electroacupuncture (EA) on noise-induced hearing loss (NIHL) in animals. A NIHL rat model was established. Electroacupuncture pretreatment at 2 Hz or posttreatmen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566032/ https://www.ncbi.nlm.nih.gov/pubmed/34745304 http://dx.doi.org/10.1155/2021/9114676 |
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author | Chang, Chia-Hao Lin, Chia-Der Hsieh, Ching-Liang |
author_facet | Chang, Chia-Hao Lin, Chia-Der Hsieh, Ching-Liang |
author_sort | Chang, Chia-Hao |
collection | PubMed |
description | Acupuncture has long been used to relieve some inner ear diseases such as deafness and tinnitus. The present study examined the effect of electroacupuncture (EA) on noise-induced hearing loss (NIHL) in animals. A NIHL rat model was established. Electroacupuncture pretreatment at 2 Hz or posttreatment at the right Zhongzhu (TE3) acupoint was applied for 1 hour. Auditory thresholds were measured using auditory brainstem responses (ABRs), and histopathology of the cochlea was examined. The results indicated that the baseline auditory threshold of ABR was not significantly different between the control (no noise), EA-only (only EA without noise), noise (noise exposure only), pre-EA (pretreating EA then noise), and post-EA (noise exposure then posttreating with EA) groups. Significant auditory threshold shifts were found in the noise, pre-EA, and post-EA groups in the immediate period after noise exposure, whereas auditory recovery was better in the pre-EA and post-EA groups than that in the noise group at the three days, one week (W1), two weeks (W2), three weeks (W3), and four weeks(W4) after noise stimulation. Histopathological examination revealed greater loss of the density of spiral ganglion neurons in the noise group than in the control group at W1 and W2. Although significant loss of spiral ganglion loss happened in pre-EA and post-EA groups, such loss was less than the loss of the noise group, especially W1. These results indicate that either pretreatment or posttreatment with EA may facilitate auditory recovery after NIHL. The detailed mechanism through which EA alleviates NIHL requires further study. |
format | Online Article Text |
id | pubmed-8566032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85660322021-11-04 Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats Chang, Chia-Hao Lin, Chia-Der Hsieh, Ching-Liang Evid Based Complement Alternat Med Research Article Acupuncture has long been used to relieve some inner ear diseases such as deafness and tinnitus. The present study examined the effect of electroacupuncture (EA) on noise-induced hearing loss (NIHL) in animals. A NIHL rat model was established. Electroacupuncture pretreatment at 2 Hz or posttreatment at the right Zhongzhu (TE3) acupoint was applied for 1 hour. Auditory thresholds were measured using auditory brainstem responses (ABRs), and histopathology of the cochlea was examined. The results indicated that the baseline auditory threshold of ABR was not significantly different between the control (no noise), EA-only (only EA without noise), noise (noise exposure only), pre-EA (pretreating EA then noise), and post-EA (noise exposure then posttreating with EA) groups. Significant auditory threshold shifts were found in the noise, pre-EA, and post-EA groups in the immediate period after noise exposure, whereas auditory recovery was better in the pre-EA and post-EA groups than that in the noise group at the three days, one week (W1), two weeks (W2), three weeks (W3), and four weeks(W4) after noise stimulation. Histopathological examination revealed greater loss of the density of spiral ganglion neurons in the noise group than in the control group at W1 and W2. Although significant loss of spiral ganglion loss happened in pre-EA and post-EA groups, such loss was less than the loss of the noise group, especially W1. These results indicate that either pretreatment or posttreatment with EA may facilitate auditory recovery after NIHL. The detailed mechanism through which EA alleviates NIHL requires further study. Hindawi 2021-10-27 /pmc/articles/PMC8566032/ /pubmed/34745304 http://dx.doi.org/10.1155/2021/9114676 Text en Copyright © 2021 Chia-Hao Chang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chang, Chia-Hao Lin, Chia-Der Hsieh, Ching-Liang Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title | Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title_full | Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title_fullStr | Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title_full_unstemmed | Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title_short | Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats |
title_sort | effect of electroacupuncture on noise-induced hearing loss in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566032/ https://www.ncbi.nlm.nih.gov/pubmed/34745304 http://dx.doi.org/10.1155/2021/9114676 |
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