Cargando…

Structural basis of gating modulation of Kv4 channel complexes

Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart(1,2). Native Kv4 tetrameric channels form macromolecular ternary complexes with two auxiliary β-subunits—intracellular Kv channel-interacting proteins...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kise, Yoshiaki, Kasuya, Go, Okamoto, Hiroyuki H., Yamanouchi, Daichi, Kobayashi, Kan, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Nakajo, Koichi, Nureki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566240/ https://www.ncbi.nlm.nih.gov/pubmed/34552243 http://dx.doi.org/10.1038/s41586-021-03935-z

Ejemplares similares

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1
por: Hagino, Tatsuya, et al.
Publicado: (2022)

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter
por: Miyauchi, Hirotake, et al.
Publicado: (2017)

Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex
por: Yamaguchi, Sonomi, et al.
Publicado: (2022)

Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies
por: Demura, Kanae, et al.
Publicado: (2020)

Functional roles of Mg(2+) binding sites in ion-dependent gating of a Mg(2+) channel, MgtE, revealed by solution NMR
por: Maruyama, Tatsuro, et al.
Publicado: (2018)

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
por: Nakamura, Ryoki, et al.
Publicado: (2020)

Structure of the type V-C CRISPR-Cas effector enzyme
por: Kurihara, Nina, et al.
Publicado: (2022)

Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8
por: Kasuya, Go, et al.
Publicado: (2022)

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
por: Kasuya, Go, et al.
Publicado: (2022)

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2
por: Kato, Takafumi, et al.
Publicado: (2022)

Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter
por: Lee, Yongchan, et al.
Publicado: (2015)

Mechanosensitive Gating of Kv Channels
por: Morris, Catherine E., et al.
Publicado: (2015)

Structural basis for translation termination by archaeal RF1 and GTP-bound EF1α complex
por: Kobayashi, Kan, et al.
Publicado: (2012)

Two HCN4 Channels Play Functional Roles in the Zebrafish Heart
por: Liu, Jiaying, et al.
Publicado: (2022)

Gating Charge Immobilization in Kv4.2 Channels: The Basis of Closed-State Inactivation
por: Dougherty, Kevin, et al.
Publicado: (2008)

Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility
por: Futamata, Haon, et al.
Publicado: (2022)

Author Correction: Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility
por: Futamata, Haon, et al.
Publicado: (2022)

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
por: Kasuya, Go, et al.
Publicado: (2017)

Structure and engineering of the minimal type VI CRISPR-Cas13bt3
por: Nakagawa, Ryoya, et al.
Publicado: (2022)

The structure of MgtE in the absence of magnesium provides new insights into channel gating
por: Jin, Fei, et al.
Publicado: (2021)

Structural basis and energy landscape for the Ca(2+) gating and calmodulation of the Kv7.2 K(+) channel
por: Bernardo-Seisdedos, Ganeko, et al.
Publicado: (2018)

Gating modulation of the KCNQ1 channel by KCNE proteins studied by voltage-clamp fluorometry
por: Nakajo, Koichi
Publicado: (2019)

Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE
por: Takeda, Hironori, et al.
Publicado: (2014)

LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae
por: Kusakizako, Tsukasa, et al.
Publicado: (2016)

Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
por: Omura, Satoshi N., et al.
Publicado: (2023)

Polyunsaturated Fatty Acids Modify the Gating of Kv Channels
por: Moreno, Cristina, et al.
Publicado: (2012)

Crystallization of the human tetraspanin protein CD9
por: Umeda, Rie, et al.
Publicado: (2019)

Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel
por: Ishida, Itzel G., et al.
Publicado: (2015)

Being Flexible: The Voltage-Controllable Activation Gate of Kv Channels
por: Labro, Alain J., et al.
Publicado: (2012)

Crystal structure of channelrhodopsin, a light-gated cation channel – all cations lead through the monomer –
por: Kato, Hideaki E., et al.
Publicado: (2013)

Voltage- and [ATP]-dependent Gating of the P2X(2) ATP Receptor Channel
por: Fujiwara, Yuichiro, et al.
Publicado: (2009)

The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels
por: Bocksteins, Elke, et al.
Publicado: (2012)

Class B1 GPCR activation by an intracellular agonist
por: Kobayashi, Kazuhiro, et al.
Publicado: (2023)

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
por: Ranjan, Rajnish, et al.
Publicado: (2019)

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
por: van der Horst, Jennifer, et al.
Publicado: (2020)

Flow and shortcuts along the Shaker Kv channel slow inactivation gating cycle
por: Nirenberg, Valerie Abigail, et al.
Publicado: (2020)

Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
por: Abd-Elsayed, Alaa, et al.
Publicado: (2019)

Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na(+) in ion-coupled drug efflux
por: Castellano, Steven, et al.
Publicado: (2021)

Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2
por: Sato, Ko, et al.
Publicado: (2021)

The S6 gate in regulatory Kv6 subunits restricts heteromeric K(+) channel stoichiometry
por: Pisupati, Aditya, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pfpiblqf0110pncm0cl715t9ci